ArticleCureus2025
Usefulness of the Geriatric Nutritional Risk Index (GNRI) as a Predictor of Postoperative Complications After Colorectal Cancer Surgery.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between the geriatric nutritional risk index and postoperative delirium: a meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Cognitive Impact of Colorectal Cancer Surgery in Elderly Patients: A Narrative Review.Cancers · 2026Review
- Comparison of PNI and GNRI nomogram models for predicting postoperative complications in elderly patients with lung cancer: a retrospective study.Frontiers in nutrition · 2026Article
- Association of preoperative prognostic nutritional index with postoperative delirium after gastric cancer surgery.Frontiers in nutrition · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPostoperative complications following colorectal cancer (CRC) surgery are known to not only impair patients' quality of life but also adversely affect long-term prognosis. Objective and simple preoperative risk assessment tools are essential for preventing such complications. The Geriatric Nutritional Risk Index (GNRI), which incorporates serum albumin concentration and the ratio of current to ideal body weight, has emerged as a useful tool for estimating the risk of postoperative complications and long-term prognosis in patients with CRC. However, detailed investigations into its association with specific postoperative complications remain limited.
methodsWe retrospectively analyzed 105 consecutive patients who underwent CRC surgery between 2021 and 2023. Preoperative GNRI was calculated for each patient, and its association with postoperative complications was assessed. For comparison, the Prognostic Nutritional Index (PNI) and the Modified Glasgow Prognostic Score (mGPS) were also evaluated for postoperative complications.
resultsReceiver operating characteristic (ROC) curve analysis identified a GNRI cutoff value of 94 for predicting complications of Clavien-Dindo grade ≥2. Patients in the high-risk group (GNRI <94) had a significantly higher incidence of grade ≥2 complications compared to the low-risk group (14/35 (40%) vs. 14/70 (20%); p=0.029). In multivariable analysis, after adjusting for known risk factors (age, sex, American Society of Anesthesiologists Physical Status (ASA-PS), preoperative obstruction, emergency surgery, surgical approach, and tumor stage), GNRI remained the only significant independent predictor (odds ratio 2.90; p=0.049). While rates of anastomotic leakage and wound infection did not differ significantly between groups, postoperative ileus (6/35 (17%) vs. 1/70 (1.4%); p=0.002) and delirium (4/35 (11%) vs. 1/70 (1.4%); p=0.023) were significantly more frequent in the high-risk group.
conclusionGNRI is a simple and effective tool for predicting postoperative complications in CRC patients. Preoperative nutritional assessment using GNRI may enhance perioperative safety and enable more personalized surgical care.
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