ArticleeNeurologicalSci2025
Pupil response as a window into cognitive processing in amyotrophic lateral sclerosis.
Article in eNeurologicalSci, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Purpose: This preliminary study aimed to investigate whether the pupil size reflects cognitive load in patients with amyotrophic lateral sclerosis (ALS). Methods: Pupil activity was monitored in three patients with ALS and a group of healthy control participants ( Results: Analysis revealed no significant difference in pupil size between patients with ALS and controls for the forward or backward spans or the control condition. Both groups demonstrated a consistent pattern of increased pupil size during the backward span task compared to the forward span task, and during the forward span task compared to the control condition. Conclusion: These findings suggest that pupil dilation reflects task-related cognitive load similarly in ALS patients and healthy controls. This supports the use of pupillometry as a non-invasive and sensitive marker of cognitive processing in ALS.
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