Evidence map›Paper›PMID 40689507›Full record

ArticleJournal of the American Heart Association2025

Nighttime Systolic Blood Pressure Determined by Pulse Transit Time Predicts Cardiac Events in Patients With Heart Failure.

Naoto Ohashi, Yu Sato, Akiomi Yoshihisa, Ryohei Takeishi, Tomofumi Misaka, Tetsuro Yokokawa, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Kazuhiko Nakazato and 1 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Nighttime Blood Pressure Matters Even in Heart Failure.Journal of the American Heart Association · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Naoto OhashiDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0009-0007-1487-0479
Yu SatoDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0003-1084-6475
Akiomi YoshihisaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0001-5574-6617
Ryohei TakeishiDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.
Tomofumi MisakaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0003-4795-9334
Tetsuro YokokawaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0001-8197-3274
Takamasa SatoDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0001-8889-9345
Masayoshi OikawaDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0009-0007-7614-8772
Atsushi KobayashiDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.
Kazuhiko NakazatoDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0002-9147-0379
Yasuchika TakeishiDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.ORCID 0000-0002-1188-4708

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe optimal systolic blood pressure (SBP) target for heart failure (HF) patients has not been established. Although the association between daytime SBP and prognosis has been reported in patients with HF, the prognostic impact of nighttime SBP remains unclear.

methodsWe conducted continuous nighttime SBP measurements noninvasively using pulse transit time in 366 patients with HF (median age, 72 years; male sex, 195), and followed up for cardiac events (HF hospitalization or cardiac death). Average values of nighttime pulse transit time -based SBP were used in the present study. The patients were divided into tertile groups based on nighttime pulse transit time-based SBP: high-SBP group (median SBP, 136 mm Hg; n=122), middle-SBP group (median SBP, 117 mm Hg; n=122), and low-SBP group (median SBP, 100 mm Hg; n=122).

resultsDuring a median follow-up period of 1083 days after nighttime pulse transit time-based SBP measurement, 71 patients experienced a cardiac event. Kaplan-Meier analysis showed the highest incidence of cardiac events in the low-SBP group. Multivariate Cox proportional hazard analysis also showed that the lowest SBP tertile was associated with a higher risk of cardiac events compared with the highest SBP tertile as reference (hazard ratio, 2.100 [95% CI, 1.121-3.933];

conclusionsLow nighttime SBP was associated with an increased cardiac event rate in patients with HF.

Indexed as

Blood PressureCardiovascular DiseasesCircadian RhythmHeart FailurePulse Wave AnalysisAgedFemaleFollow-Up StudiesHospitalizationHumansKaplan-Meier EstimateMalePredictive Value of TestsPrognosisSystoleTime Factorsarterial stiffnesscardiac functionheart failurenighttime blood pressurepulse transit time

Identifiers

PMID40689507
PMCPMC12449993

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.