Evidence map›Paper›PMID 40689635›Full record

ArticleJournal of bacteriology2025

Pyrimidine sufficiency is required for Sae two-component system signaling in

Dennis A DiMaggio, Won-Sik Yeo, Shaun R Brinsmade

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Comparison ofMicrobiology (Reading, England) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Dennis A DiMaggioDepartment of Biology, Georgetown University, Washington, DC, USA.ORCID 0000-0002-2093-2345
Won-Sik YeoDepartment of Biology, Georgetown University, Washington, DC, USA.ORCID 0000-0002-6296-6404
Shaun R BrinsmadeDepartment of Biology, Georgetown University, Washington, DC, USA.ORCID 0000-0002-5381-2817

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
Nutritional regulation of pathogenesis in Staphylococcus aureusR01AI137403 · NIAID · GEORGETOWN UNIVERSITY · PI BRINSMADE, SHAUN R · 2018 to 2022
$2.2M
High-Throughput DNA SequencerS10OD032203 · OD · TUFTS UNIVERSITY BOSTON · PI TAI, ALBERT K · 2022 to 2022
$804k
Role of branched-chain fatty acids in physiology and virulence of Staphylococcus aureusR56AI137403 · NIAID · GEORGETOWN UNIVERSITY · PI BRINSMADE, SHAUN R · 2024 to 2024
$481k
NCI NIH HHS P30 CA051008NIAID NIH HHS R01 AI137403NIAID NIH HHS R56 AI137403NIH HHS R01 AI137403NIH HHS R56 AI137403NIH HHS S10 OD032203
6 · The paper itself

Abstract

Nucleotide metabolism in pathogens is essential for their virulence, supporting their growth, survival, and immune evasion during infection. Virulence in

Indexed as

Bacterial ProteinsHistidine KinaseProtein KinasesPyrimidinesSignal TransductionStaphylococcus aureusGene Expression Regulation, BacterialVirulenceBacterial ProteinsHistidine KinaseProtein KinasespyrimidinePyrimidinesSaeS protein, Staphylococcus aureusfree fatty acidsmembranemetabolismMRSApyrimidinepyrimidine metabolismSaeRSStaphylococcus aureustwo-component regulatory systemsvirulencevirulence regulation

Identifiers

PMID40689635
PMCPMC12369341

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.