Evidence map›Paper›PMID 40689997›Full record

SynthesisEuropean radiology2026

Comparison of [

Yueling Deng, Xiao Zhang, Yangmeihui Song, Xiaoli Lan

Abstract readMeta-AnalysisSystematic ReviewComparative Study
PubMed Publisher
In one paragraph

Synthesis in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yueling DengDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiao ZhangDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yangmeihui SongDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaoli LanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lxl730724@hotmail.com.ORCID http://orcid.org/0000-0002-7263-7399

Funding

Hubei Province Science and Technology Innovation Team [2022] No. 72Key Project of Hubei Province Natural Science Foundation No. 2021CFA008National Natural Science Foundation of China No. 82030052
6 · The paper itself

Abstract

objectivesThis study aimed to systematically compare the efficacy of [ MATERIALS AND

methodsA comprehensive literature search was conducted across PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov. The study focused on comparing time-to-event hazard ratios (HRs) between patients categorized as complete response (CR) and non-complete response (non-CR) based on the two imaging assessment modalities. Eligible studies were selected based on the availability of both survival data and appropriate imaging methods, with special attention to the use of CT as part of PET/CT protocols in some cases. Additionally, PET and CT assessments were paired for each individual to analyze the efficacy of these imaging methods in detecting CR, assess the mismatch rate, and identify its causes.

resultsA review of 1445 candidate articles identified 15 eligible studies involving 952 patients. For CR and non-CR patients, the combined HR for PET was 4.10 (95% CI = 2.71-6.19), while for CT it was 1.25 (95% CI = 0.63-2.46). The high rate of PET-/CT+ discordance (48%, 95% CI: 42-53%) indicates that CT frequently misclassifies residual inflammation or fibrosis as active disease, whereas the absence of PET+/CT- cases (0%, 95% CI: 0-3%) highlights the high specificity of PET in detecting true residual tumors.

conclusionThis evidence supports prioritizing [ KEY POINTS: Question How do [

Indexed as

Fluorodeoxyglucose F18ImmunotherapyMelanomaPositron Emission Tomography Computed TomographySkin NeoplasmsTomography, X-Ray ComputedHumansRadiopharmaceuticalsTreatment OutcomeFluorodeoxyglucose F18RadiopharmaceuticalsComputed tomographyImmunotherapyMelanomaPositron emission tomographyResponse evaluation criteria in solid tumors

Identifiers

PMID40689997

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.