ReviewProbiotics and antimicrobial proteins2026
Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.
Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In general, endodontic infections are polymicrobial infections, and the severity of the infection depends on the pathogenicity of the microbes and the resistance of the host. For the treatment of endodontic infections, antibiotics are widely used; however, the development of resistance raises concerns for their wide-scale application; hence, there is always an unmet need to develop alternative treatment strategies in the fight against endodontic infection. Basically, the searches were conducted in PubMed (459), Science Direct (559 articles), and WOS (493) using keywords and phrases to identify relevant articles. Search criteria consisted of combinations of the following words and phrases: Bioactive peptides, endodontic infections, oral microbiota, intraradicular infections, extraradicular infections, In vitro, In vivo study, clinical trials, mechanism of peptides, oral biofilm. It is important to note that bioactive peptides are short sequences of 2-40 amino acids, displaying various functional and structural diversities, and exhibiting a wide range of therapeutic activity. This comprehensive review discusses various aspects related to bioactive peptide sources; chemistry; biosynthesis; bioavailability; safety along with the periradicular disease, oral microbiota, and microbial analysis; molecular mechanisms of pathogenicity; host susceptibility; prediction markers; focal infection; and bioactive peptide resistance as well as approaches to overcome peptide resistance. Overall, this review will enlighten the readers with the prospective potential of bioactive peptides against endodontic infections.
Indexed as
Identifiers
40690088What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.