SynthesisRedox biology2025
Associations of selenium status with all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies.
Synthesis in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Selenium nutritional status and cardiovascular diseases: mechanisms of cardioprotection and 21 years of global research trends in precision prevention (2005-2026).Frontiers in nutrition · 2026Pooled it
- Biofortification of Sprouts and Microgreens with Trace Elements and Calcium.Molecules (Basel, Switzerland) · 2026Review
- Vascular Aging and Atherosclerosis: The Modulatory Impact of Selenium-A Comprehensive Review.Cells · 2026Review
- All-Cause Mortality and Cancer Risk Dependent on Blood Se Level and HRG rs10770 Genotypes on a Prospective Cohort of Women with Familial Breast Cancers.International journal of molecular sciences · 2026Article
- Perioperative high-dose selenium supplementation in open thoracic aortic surgery: a post hoc subgroup analysis of the SUSTAIN CSX trial.Journal of thoracic disease · 2026Article
- Selenoprotein P Deficiency Is Associated with Early Signs of Kidney Disease and Hospitalization Risk in Heart Failure.Nutrients · 2026Article
- Targeting VSMCs to suppress macrophage-like phenotype switching that restrains atherogenesis by immunosuppressive oligodeoxynucleotide (A151) functionalized selenium nanoparticles.Journal of nanobiotechnology · 2025Article
- Selenium Nanoparticles as Versatile Delivery Tools.Pharmaceutics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo provide a systematic review and meta-analysis of population-based cohort studies on the association of selenium status with all-cause and cause-specific mortality.
methodsRelevant studies were identified through systematic searches of MEDLINE and ISI Web of Knowledge. Risk ratios (RRs) reported across categories of selenium biomarkers were recalculated as continuous RR estimations per standard deviation (SD) using generalized least squares for linear trend estimation and pooled in random effects meta-analyses.
resultsThe literature search identified 20 studies, including 17 studies on all-cause mortality, 9 studies on cardiovascular mortality and 7 on cancer mortality. An increase of selenium biomarker concentration by one SD was associated with 13 % lower all-cause mortality (RR [95 %-confidence interval], 0.87 [0.83-0.90]), 11 % lower cardiovascular mortality (0.89 [0.84-0.94]) and 15 % lower cancer mortality (0.85 [0.78-0.94]). Although moderate heterogeneity was observed, the inverse association with all-cause mortality was robust across countries with low or adequate selenium supply, selenium measurement methods, recruitment years, study quality scores, follow-up lengths and sample sizes. The trim and fill method showed no indications of relevant publication bias.
conclusionSelenium biomarkers are inversely associated with all-cause, cardiovascular and cancer mortality in the general population and clinical trials among selenium deficient populations are still needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.