Evidence map›Paper›PMID 40691275›Full record

ReviewNature reviews. Rheumatology2025

Addressing the challenge of global delays in diagnosis and treatment of systemic lupus erythematosus.

Guillermo J Pons-Estel, María Fernanda Ramírez-Flores, Rosana Quintana, Sang-Cheol Bae, Dzifa Dey, Bernardo A Pons-Estel, Ingris Peláez-Ballestas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guillermo J Pons-EstelGrupo Oroño - Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina. gponsestel@gmail.com.ORCID http://orcid.org/0000-0002-0647-929X
María Fernanda Ramírez-FloresUniversidad Nacional Autónoma de México, Programa de Estudios Combinados en Medicina (PECEM), Facultad de Medicina, Mexico City, Mexico.ORCID http://orcid.org/0000-0002-7843-4816
Rosana QuintanaGrupo Oroño - Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina.
Sang-Cheol BaeDepartment of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Hanyang University Institute for Rheumatology Research and Hanyang Institute of Bioscience and Biotechnology, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0003-4658-1093
Dzifa DeyRheumatology Unit, Korle Bu Teaching Hospital, Accra, Ghana.
Bernardo A Pons-EstelGrupo Oroño - Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina.
Ingris Peláez-BallestasRheumatology Unit, Hospital General de México Dr. Eduardo Liceaga, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-5188-7375

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus is a complex and increasingly prevalent disease that presents substantial challenges in both diagnosis and management. Diagnostic delays frequently lead to irreversible organ damage, and remain a crucial concern, mainly among vulnerable populations, such as minority ethnic groups and those living in the global south. These delays are exacerbated by the clinical heterogeneity of systemic lupus erythematosus, the lack of specific diagnostic biomarkers, gaps in disease awareness or medical training, and persistent health care disparities, particularly in low-resource settings. This Perspective highlights the urgent need for a standardized definition of diagnostic delay that accounts for both clinical and socio-economic factors. By prioritizing early intervention and expanding access to specialized care, we can improve patient outcomes and reduce the long-term burden of the disease.

Indexed as

Delayed DiagnosisLupus Erythematosus, SystemicGlobal HealthHealthcare DisparitiesHealth Services AccessibilityHumans

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.