SynthesisClinical and experimental medicine2025
The influence of antioxidant supplementation on adverse effects and tumor interaction during radiotherapy: a systematic review.
Synthesis in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- NADPH oxidase 3 inhibition preserves hearing in mice after stereotactic radiosurgery.Molecular therapy. Nucleic acids · 2026Article
- Photodynamic Therapy in Cancer: Mechanisms, Photosensitizer Technology, Vitamin Modulation, and Rational Combination Design.Biomedicines · 2026Review
- Herbal Products and Dietary Supplements in Radiation Oncology: Evidence, Safety, and Practical Patient Counseling.Seminars in radiation oncology · 2026Review
- Article
- Surgical Management of Advanced Mandibular Osteonecrosis Utilizing a Contemporary Mandibular Reconstruction Plate in Patients Unsuitable for Free Flap Reconstruction-Preliminary Study and Case Series.Journal of clinical medicine · 2026Article
- Advances in the Prevention and Treatment of Radiation Skin Injury: Mechanisms, Pharmacological Interventions, and Applications of Novel Dressings.International journal of nanomedicine · 2026Review
- Head and Neck Radiotherapy and Dentomaxillofacial Diagnostic Imaging: Biological Interactions and Protective Approaches.Biomedicines · 2025Review
- Integrative Oncology Approaches Beneficial to Patients in Radiation Therapy.Current oncology reports · 2025Review
- Research Progress on Dietary Intervention in Radiation Protection.Dose-response : a publication of International Hormesis SocietyReview
- A Modern Odyssey of Prevention: Integrating Nutrition and Lifestyle in Radiation Mitigation- A Narrative Review.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy is essential in cancer treatment, using ionizing radiation to generate free radicals in the irradiated tissue or to directly damage DNA. Despite comprehensive safety measures, healthy tissue is also irradiated, causing side effects like oral mucositis and dermatitis. Antioxidants, which are known for scavenging free radicals, may reduce these adverse effects, but their impact on radiotherapy efficacy remains unclear. The aim of this systematic review was to evaluate the influence of antioxidant supplementation on radiation-induced side effects, tumor outcome and quality of life. In April 2024, a systematic research was conducted searching five databases (Medline, CINAHL, EMBASE, Cochrane CENTRAL, PsycINFO) to find studies looking at the effect of antioxidant supplementation during radiotherapy on radiation-induced side effects and parameters of tumor outcome or survival. Antioxidants can mitigate radiation-induced side effects, with vitamins C and E showing positive effects on oral mucositis, xerostomia and cardiac function. Curcumin and EGCG improved symptoms such as mucositis, dermatitis and esophagitis, while glutathione-enhanced treatment compliance but did not provide significant protection against side effects. However, multiple studies indicate that the concurrent use of antioxidants during cancer treatment may impair tumor control, increase recurrence rates and reduce survival outcomes. Antioxidants may reduce radiation-induced side effects but could compromise treatment efficacy. Due to inconsistent evidence and potential risks, clinical recommendations are premature. Further high-quality research is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.