ArticleNature cell biology2025
TMEM65 functions as the mitochondrial Na
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Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Asymmetric distribution of mitochondrial CaExperimental & molecular medicine · 2026Article
- Mitochondrial Toxicology of Heavy Metals and Pesticides: Transport Systems, Mitochondrial Dysfunction and Permeability Transition.International journal of molecular sciences · 2026Review
- Molecular mechanisms of mitochondrial CaNature communications · 2026Article
- The role of mitochondrial Na⁺/Ca²⁺ exchanger in brain cell aging.Journal of bioenergetics and biomembranes · 2026Review
- Nrf2 modulates cytosolic and mitochondrial calcium signal.Redox biology · 2026Article
- Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.The EMBO journal · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Mitochondrial homeostasis: the central hub governing the progression of atherosclerosis.Precision clinical medicine · 2026Review
- Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter.Nature communications · 2026Article
- Loss of TMEM65 in mice causes mitochondrial disease mediated by mitochondrial CaNature communications · 2026Article
- Molecular mechanisms of mitochondrial CabioRxiv : the preprint server for biology · 2026Article
- Mitochondrial CaBiomolecules · 2026Review
- Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish.Communications biology · 2026Article
- The role of calcium homeostasis dysregulation in allergic rhinitis.Frontiers in immunology · 2026Review
- Identification of characteristic hub genes in the immune-active phase of chronic hepatitis B.Frontiers in immunology · 2026Article
- TMEM65-dependent Ca2+ extrusion safeguards mitochondrial homeostasis.Nature communications · 2025Article
- Sensing within: Mitochondrial inside-out signal transduction.Cell chemical biology · 2025Review
- Mitochondrial sodium-calcium exchange-Can TMEM65 do it alone?Cell metabolism · 2025Article
- Calcium Signaling and Cardiac Adaptation to Stress: Focus on Pregnancy and Diabetes.Biomolecules · 2025Review
- Exploring the interplay between mitochondria and endoplasmic reticulum in pulmonary arterial hypertension.Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Jim Lu Zhang *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3748-4603
Yu-Chen Chang *Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Po-Hsuan LaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Han-I YehDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Chen-Wei TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yu-Lun HuangDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Tsung-Yun LiuDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
I-Chi LeeDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
North FoulonDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Yan XuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Bing RaoDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9895-4133
Hsiu-Man ShihDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Yung-Chi TuDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Andres V ReyesDepartment of Plant Biology and Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA, USA.
Shou-Ling XuDepartment of Plant Biology and Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6741-9506
Liang FengDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. liangf@stanford.edu.ORCID http://orcid.org/0000-0001-6171-2050
Ming-Feng TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. vmf6uw@virginia.edu.ORCID http://orcid.org/0000-0003-4277-1885
Funding
Molecular mechanisms of mitochondrial membrane transport systems in cellular energeticsR35GM153424 · NIGMS · STANFORD UNIVERSITY · PI Liang Feng · 2024 to 2026
$2.5MMolecular mechanisms of the mitochondrial calcium transport systemR35GM151958 · NIGMS · UNIVERSITY OF VIRGINIA · PI Ming-Feng Tsai · 2024 to 2026
$1.6MMolecular Physiology of Mitochondrial Calcium TransportersR01GM144485 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI TSAI, MING-FENG · 2021 to 2023
$968kThermo Orbitrap Eclipse Tribrid with ETD and an Ultimate 3000 RSLCnano SystemS10OD030441 · OD · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2022 to 2022
$600kNIGMS NIH HHS R01 GM144485NIGMS NIH HHS R35 GM151958NIGMS NIH HHS R35 GM153424NIH HHS S10 OD030441U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10OD030441U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35-GM151958
Abstract
Mitochondria export Ca
Indexed as
Membrane ProteinsMitochondriaMitochondrial ProteinsSodium-Calcium ExchangerAnimalsBinding SitesCalciumCalcium SignalingClonazepamHEK293 CellsHumansMiceMice, Inbred C57BLMice, KnockoutThiazepinesCalciumCGP 37157ClonazepamMembrane ProteinsMitochondrial ProteinsSodium-Calcium ExchangerThiazepines
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.