Trial reportScientific reports2025
Direct carotid sinus nerve stimulation in anesthetized human subjects.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06969846 (Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects
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0 citing papers in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies. Directly stimulating the carotid sinus nerve (CSN) is known to potentially reduce blood pressure (BP) but its clinical efficacy has not been consistently demonstrated with existing electrode technologies in humans. We investigated the effect of acute direct CSN stimulation on BP and HR in anesthetized humans using an application-specific multi-contact electrode. Using a novel surgical approach, a custom electrode was implanted around tissue including CSN branches in anesthetized adults. Following functional mapping, presumed baroafferent fibers were identified via response and stimulated. Outcome measures included change in systolic BP (SBP), diastolic BP (DBP), and heart rate (HR) during and after stimulation using multi-level modeling. Secondarily, dose dependency was examined. In 13 subjects, stimulation caused a 24 ± 20 mmHg (mean ± SD, p < 0.01) maximum drop in SBP, with associated drops in DBP (11 ± 9 mmHg, p < 0.01) and HR (10 ± 9 bpm, p < 0.05). In subjects with baseline SBP > 120 mmHg (n = 8), maximum SBP drop was 31 ± 23 mmHg, while subjects with baseline SBP < 120 mmHg (n = 5) exhibited a maximum SBP drop of 11 ± 3 mmHg. In all patients, BP and HR recovered rapidly with stimulus withdrawal. There were results suggesting a positive dose (electrical current) response relationship. Using a novel surgical approach and application specific electrode, direct stimulation of the carotid sinus nerve in anesthetized human subjects caused a marked concurrent drop in BP/HR followed by rapid recovery with stimulation withdrawal. There was an indication of dose dependency.This study was registered as ClinicalTrials.gov ID NCT06969846, May 9, 2025.
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