Evidence map›Paper›PMID 40691736›Full record

ArticleJournal of neurology2025

The predictive value of social cognition assessment for 1-year follow-up functional outcomes in behavioral variant frontotemporal dementia.

Electra Chatzidimitriou, Yu Chen, Despina Moraitou, Panagiotis Ioannidis, Eleni Aretouli, Joel H Kramer, Bruce L Miller, Marilu Gorno-Tempini, William W Seeley, Howard J Rosen and 1 more

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Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Electra ChatzidimitriouMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. electra_hatzidimitriou@hotmail.com.ORCID http://orcid.org/0000-0003-2136-5220
Yu ChenMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Despina MoraitouDepartment of Cognition, Brain and Behavior, School of Psychology, Faculty of Philosophy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Panagiotis Ioannidis2nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Eleni AretouliDepartment of Psychology, School of Social Sciences, University of Ioannina, Ioannina, Greece.
Joel H KramerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Marilu Gorno-TempiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
William W SeeleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Howard J RosenMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Katherine P RankinMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
Attention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal DementiaRF1AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2019 to 2019
$4.0M
Measuring Altered Social Behavior in Neurodegenerative DiseaseR01AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2008 to 2018
$3.6M
Larry L. Hillblom Foundation 2014-A-004-NETNational Institutes of Health (NIH) P01AG019724National Institutes of Health (NIH) P30AG062422National Institutes of Health (NIH) P50AG023501National Institutes of Health (NIH) R01/RFIAG029577NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG029577NIA NIH HHS RF1 AG029577NINDS NIH HHS R01 NS050915NINDS NIH HHS RF1 NS050915
6 · The paper itself

Abstract

BACKGROUND AND

objectivesBehavioral variant frontotemporal dementia (bvFTD) is characterized by prominent socioemotional deficits that negatively impact daily living. This study aims to identify the strongest socioemotional predictors of functional status at 1-year follow-up and examine whether socioemotional assessment provides additional predictive value for functional outcomes beyond neuroimaging data in bvFTD.

methodsA total of 78 bvFTD patients were assessed at baseline using a comprehensive social cognition battery and the Functional Activities Questionnaire (FAQ), and were reassessed 1 year later to examine longitudinal changes in their functional abilities. Regression modeling was performed to identify the strongest socioemotional predictors of functional outcomes at 1-year follow-up. In a subset of 57 patients with available baseline MRI data, the volumes of functional brain networks particularly vulnerable in bvFTD were obtained using voxel-based morphometry. Hierarchical regression analysis was employed to compare the predictive value of social cognition measures above neuroimaging data.

resultsNeuropsychological tests assessing socioemotional semantic knowledge, sarcasm perception and cognitive perspective taking appeared to be the strongest socioemotional predictors of FAQ at the 1-year-follow-up assessment. The structural MRI data alone accounted for 42.01% of the variance in FAQ outcome, but increased to 55.85% when social cognition measures were included in the model (p < 0.001).

conclusionsThis study highlights the significant contribution of quantifying social cognition in predicting which bvFTD patients are more likely to quickly develop adverse functional outcomes. Integrating socioemotional assessments in clinical practice with bvFTD can significantly enhance clinicians' prognostic accuracy for functional outcomes, thus informing refined treatment strategies for these individuals.

Indexed as

Frontotemporal DementiaSocial CognitionAgedBrainFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPredictive Value of TestsBvFTDFunctional outcomesPredictive modelingSocial cognitionSocioemotional assessmentStructural neuroimaging

Identifiers

PMID40691736
PMCPMC12991054

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.