Evidence map›Paper›PMID 40691826›Full record

ArticleBMC cancer2025

Enhancing treatment outcomes after gynaecological cancer (ACUMEN): a randomised controlled exercise trial protocol.

Vivian Chiu, Alexander Boytar, Brent Cunningham, Tina Skinner, Jane Turner, Debra Anderson, Asaduzzaman Khan, Tom Bailey, Janine Porter-Steele, Leonie Young and 11 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Vivian ChiuSchool of Nursing, Midwifery and Social Work, The University of Queensland, Level 3, Chamberlain Building (35), St Lucia, QLD, 4072, Australia. vivian.chiu@uq.edu.au.
Alexander BoytarFaculty of Kinesiology & Physical Education, The University of Toronto, Toronto, Canada.
Brent CunninghamSchool of Nursing, Midwifery and Social Work, The University of Queensland, Level 3, Chamberlain Building (35), St Lucia, QLD, 4072, Australia.
Tina SkinnerSchool of Health Sciences, University of New South Wales, Sydney, Australia.
Jane TurnerSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia.
Debra AndersonFaculty of Health, University of Technology Sydney, Sydney, Australia.
Asaduzzaman KhanSchool of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia.
Tom BaileySchool of Health, University of the Sunshine Coast, Sunshine Coast, Australia.
Janine Porter-SteeleGriffith Health Group, Griffith University, Gold Coast, Australia.
Leonie YoungWesley Research Institute, The Wesley Hospital, Brisbane, Australia.
Haitham TuffahaCentre for the Business and Economics of Health, The University of Queensland, Brisbane, Australia.
Lewis PerrinMater Hospital, Brisbane, Australia.
Andrea GarrettWesley Research Institute, The Wesley Hospital, Brisbane, Australia.
Jeffrey GohIcon Cancer Centre, Greenslopes Private Hospital, Brisbane, Australia.
Grace RoseSchool of Health, University of the Sunshine Coast, Sunshine Coast, Australia.
Briana CliffordSchool of Health Sciences, University of New South Wales, Sydney, Australia.
Sjaan GomersallSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia.
Darren KorbieCentre for Personalized NanoMedicine, The University of Queensland, Brisbane, Australia.
Nicolas ConstantinCentre for Personalized NanoMedicine, The University of Queensland, Brisbane, Australia.
Jackie LiSchool of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia.
Alexandra Leigh McCarthySchool of Nursing, Midwifery and Social Work, The University of Queensland, Level 3, Chamberlain Building (35), St Lucia, QLD, 4072, Australia.

Funding

Medical Research Future Fund (MRFF) APP1199890
6 · The paper itself

Abstract

backgroundTreatment for gynaecological cancer often entails challenges that negatively affect quality-of-life. While exercise has been shown to improve physical and psychosocial well-being during cancer recovery, affected women often avoid exercise due to the specific health challenges they face after treatment. The Enhancing treatment outcomes after gynaecological cancer (ACUMEN) program aims to enhance health-related quality of life in this group by promoting lifelong exercise habits.

methodsThe ACUMEN trial is a single-blind, multi-centre randomised controlled trial that evaluates the impact of a structured exercise intervention on quality of life in women who have completed primary treatment for gynaecological cancer within the last 60 months. A total of 342 participants will be randomly assigned to either usual care or an intervention group. The intervention involves a 12-week personalised exercise program, where participants will complete three 1-h exercise sessions per week. During the first six weeks, participants will receive two supervised sessions with accredited exercise physiologists or physiotherapists and self-manage one session per week. In the following six weeks, this shifts to one supervised session and two self-managed sessions weekly, with goal of fostering sustainable, self-managed exercise habits. Assessments will take place at baseline, Week 12 (end of intervention), and Week 24 (end of maintenance). The primary outcome is health-related quality of life, measured by the Short Form-36. Secondary outcomes include exercise self-efficacy, body composition, symptoms of lymphoedema, physical fitness, biological markers, and habitual physical activity levels. For intervention group participants assigned accredited exercise physiologists or physiotherapists will track attendance, adherence, feasibility, and safety. DISCUSSION: The ACUMEN trial will evaluate whether a structured exercise program improves health-related quality of life in women recovering from gynaecological cancer treatment. The findings will help determine if the intervention is effective and sustainable, with a simultaneous cost-effectiveness analysis conducted to assess its value for money. Results from this study could inform future exercise-based interventions to enhance cancer recovery.

trial registrationAustralian New Zealand Clinical Trial Registry (ACTRN12621000050853, registered 19/01/2021).

Indexed as

ExerciseExercise TherapyGenital Neoplasms, FemaleQuality of LifeAdultFemaleHumansMiddle AgedMulticenter Studies as TopicRandomized Controlled Trials as TopicSingle-Blind MethodTreatment OutcomeCancer recoveryExercise interventionGynaecological cancerQuality of lifeSelf-efficacy

Identifiers

PMID40691826
PMCPMC12278665

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.