Evidence map›Paper›PMID 40692140›Full record

ArticleASN neuro2025

Identifying Lanthionine Ketimine Derivatives for Maturation and Proliferative Effects in Oligodendrocyte Progenitor Cells.

Zachary McDonald, Ankit Tandon, Travis T Denton, Mehek Taneja, Jacqueline Rocha, Jeffrey L Dupree, Pablo M Paez, Veronica T Cheli, Swathi G Tumuluri, Douglas L Feinstein

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zachary McDonaldDepartment Anesthesiology, University of Illinois, Chicago, Illinois, USA.
Ankit TandonDepartment Anesthesiology, University of Illinois, Chicago, Illinois, USA.
Travis T DentonDepartment of Pharmaceutical Sciences, College of Pharmacy & Pharmaceutical Sciences, Washington State University Health Sciences Spokane, Spokane, Washington, USA.
Mehek TanejaDepartment Anesthesiology, University of Illinois, Chicago, Illinois, USA.
Jacqueline RochaDepartment Anesthesiology, University of Illinois, Chicago, Illinois, USA.
Jeffrey L DupreeDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.
Pablo M PaezInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York, USA.
Veronica T CheliInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York, USA.
Swathi G TumuluriInstitute for Myelin and Glia Exploration, Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, New York, USA.
Douglas L FeinsteinDepartment Anesthesiology, University of Illinois, Chicago, Illinois, USA.

Funding

BLRD VA I01 BX002565RRD VA I01 RX003955
6 · The paper itself

Abstract

Previous studies have shown that lanthionine ketimine ethyl ester (LKE) reduces clinical scores in the experimental autoimmune encephalomyelitis (EAE) mouse model of Multiple Sclerosis, induces differentiation of oligodendrocyte progenitor cells (OPCs) in vitro, and accelerates remyelination following cuprizone induced demyelination. In a search for derivatives with greater efficacy to induce OPC maturation or proliferation, we screened a panel of 2-alkyl and 3-phosphonate substituted LK derivatives. Incubation of Oli-neu oligodendrocyte cells with 2-

Indexed as

Amino Acids, SulfurCell DifferentiationCell ProliferationOligodendrocyte Precursor CellsOligodendrogliaAnimalsBasic Helix-Loop-Helix ProteinsCells, CulturedMiceMice, Inbred C57BLNerve Tissue ProteinsOligodendrocyte Transcription Factor 2Amino Acids, SulfurBasic Helix-Loop-Helix Proteinslanthionine ketimineNerve Tissue ProteinsOligodendrocyte Transcription Factor 2differentiationmyelinoligodendrocyteOli-neu cellsproliferation

Identifiers

PMID40692140
PMCPMC12296138

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.