Evidence map›Paper›PMID 40692144›Full record

ArticleCurrent neuropharmacology2026

Research Hotspots and Frontiers of Ischemic Stroke and Traditional Chinese Medicine: A Knowledge Mapping and Text Mining Analysis.

Jian Xie, Teng Li, Yuan Zhang

Abstract read
In one paragraph

Article in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jian XieDepartment of Neurology in Affiliated ZhongDa Hospital and Jiangsu Provincial Medical Key Discipline, School of Medicine, Institution of Neuropsychiatry, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu, 210009, China.
Teng LiDepartment of Laboratory Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Yuan ZhangDepartment of Pharmacy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.ORCID 0000-0002-7970-6211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveIschemic stroke is a complex neurological disease with poor prognosis, resulting in significant economic burdens for patients, their families, and society at large. Traditional Chinese Medicine (TCM) offers unique advantages and has been utilized for thousands of years in the prevention and treatment of ischemic stroke. However, there is currently a lack of bibliometric analysis and knowledge mapping regarding TCM treatments for this condition. To identify the key areas and future directions of TCM treatment for Ischemic Stroke.

methodsWe extracted articles on TCM treatments for ischemic stroke from the Web of Science Core Collection (WoSCC) database, spanning from January 1, 1990, to March 20, 2025, and conducted a bibliometric analysis. Data processing was performed using CiteSpace, VOSviewer, and Origin2024b.

resultsWe collected 506 published papers, with China accounting for the majority of these publications (97.0 %, 418 articles). The Journal of Ethnopharmacology and Frontiers in Pharmacology were the two most frequently published journals. The leading institutions contributing to this research included the Chinese Academy of Medical Sciences, Beijing University of Chinese Medicine, and Peking Union Medical College (now known as Capital Medical University). The primary research hotspots in TCM treatment for ischemic stroke focused on protective effects, brain injury, and neural regeneration. Notably, network pharmacology, molecular docking, and metabolomics were identified as the commonly used research methods. Among them, network pharmacology was the most frequently used research method. Additionally, we summarized the TCM remedies that have been extensively researched and cited in the context of ischemic stroke, including catalpol, angong niuhuang wan, buyang huanwu decoction, jeo-dang-tang, yiqifumai powder injection, and gualou guizhi decoction.

conclusionThe work highlights the key topics and recent research frontiers, providing valuable resources for scholars interested in the role of TCM in treating ischemic stroke.

Indexed as

Brain IschemiaData MiningDrugs, Chinese HerbalIschemic StrokeMedicine, Chinese TraditionalAnimalsBibliometricsHumansDrugs, Chinese HerbalbibliometricsIschemic strokenetwork pharmacologyneural regenerationTCM

Identifiers

PMID40692144
PMCPMC13519839

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.