Evidence mapPaperPMID 40692212Full record

ReviewAnimal models and experimental medicine2025

Strategies for optimization of hypoglycemia rat models.

Lee Yeong Zher, Eason Kong Qi Zheng, Rayneshia Elaura Raymond, Ye Zhen Jie, Christina Gertrude Yap

Abstract readReview
In one paragraph

Review in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Strategies for optimization of hypoglycemia rat models.Animal models and experimental medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lee Yeong ZherJeffrey Cheah School of Medicine and Health Sciences, Monash University, Subang Jaya, Malaysia.ORCID 0009-0005-7048-9045
Eason Kong Qi ZhengJeffrey Cheah School of Medicine and Health Sciences, Monash University, Subang Jaya, Malaysia.ORCID 0009-0004-8128-1955
Rayneshia Elaura RaymondFaculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Ye Zhen JieFaculty of Medicine, Bioscience and Nursing, MAHSA University, Kuala Lumpur, Malaysia.
Christina Gertrude YapJeffrey Cheah School of Medicine and Health Sciences, Monash University, Subang Jaya, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review focuses on rat models for studying the short-term and long-term effects of mild and severe hypoglycemia. We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experimental models. This study aims to investigate the therapeutic potential of phytotherapeutic agents and their efficacy in mitigating the adverse effects of hypoglycemia. Insights from our planned research will be beneficial in improving quality of life for individuals at risk of episodes of low blood sugar. Optimizing hypoglycemic rat models for research requires selecting a suitable experimental model that will be susceptible to hypoglycemia induction, effective monitoring of blood glucose levels, and maintaining a high survival rate throughout the required experimental duration.

Indexed as

Disease Models, AnimalHypoglycemiaAnimalsBlood GlucoseRatsBlood Glucosehypoglycemiain vivo studyphytotherapeutic agentsrat modeltherapeutic developmenttranslational research

Identifiers

PMID40692212
PMCPMC12531110

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.