ArticleFrontiers in medicine2025
Analysis of gene polymorphisms in patients with pulmonary infections based on next-generation sequencing technology and their prognostic predictive value.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pulmonary infections are a leading cause of morbidity and mortality worldwide, particularly among vulnerable populations such as children and the older adult. Gene polymorphisms play a critical role in disease susceptibility, progression, and prognosis, yet their specific contributions to pulmonary infections remain underexplored. This study utilized next-generation sequencing (NGS) technology to analyze gene polymorphisms in 200 patients with pulmonary infections and evaluate their prognostic value. Key findings include significant associations between polymorphisms in TLR4 (rs4986790), IL-10 (rs1800896), TNF-α (rs1800629), and MBL2 (rs1800450) with infection susceptibility, disease severity, and survival outcomes. Notably, carriers of the TLR4 rs4986790 mutation exhibited increased risk of severe infections and prolonged hospital stays, while IL-10 rs1800896 was linked to higher
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