Evidence map›Paper›PMID 40692967›Full record

ReviewFrontiers in global women's health2025

Research advances and future directions in female ADHD: the lifelong interplay of hormonal fluctuations with mood, cognition, and disease.

J J Sandra Kooij, Maxime de Jong, Jessica Agnew-Blais, Silvia Amoretti, Kathrine Bang Madsen, Isabella Barclay, Sven Bölte, Charlotte Borg Skoglund, Thomas Broughton, Sara Carucci and 21 more

Abstract readReview
In one paragraph

Review in Frontiers in global women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Important Health Care Components to Promote Sexual and Reproductive Health Among Young Women With Attention-Deficit/Hyperactivity Disorder: A Delphi Study.Health expectations : an international journal of public participation in health care and health policy · 2026
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  12. Practical tools for female-specific ADHD: The impact of hormonal fluctuations in clinical practice and from the literature.European psychiatry : the journal of the Association of European Psychiatrists · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

J J Sandra KooijDepartment of Psychiatry, Amsterdam University Medical Center/VUmc, Amsterdam, Netherlands.
Maxime de JongExpertise Center Adult ADHD, PsyQ, Psycho-medical Programs, The Hague, Netherlands.
Jessica Agnew-BlaisDepartment of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.
Silvia AmorettiGroup of Psychiatry, Mental Health and Addictions, Vall D'Hebron Research Institute (VHIR), Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Barcelona, Spain.
Kathrine Bang MadsenDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
Isabella BarclayCentre for Neuropsychiatric Genetics and Genomics & Wolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, United Kingdom.
Sven BölteCenter of Neurodevelopmental Disorders (KIND), Department of Women's and Children's Health, Centre for Psychiatry Research, Karolinska Institutet & Region Stockholm, Stockholm, Sweden.
Charlotte Borg SkoglundDepartment of Womens and Childrens Health, Uppsala University, Uppsala, Sweden.
Thomas BroughtonDepartment of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.
Sara CarucciDepartment of Medical Sciences and Public Health, University of Cagliari and Child and Adolescent Unit P.O. Microcitemico ASL Cagliari, Cagliari, Italy.
Dorenda K E van DijkenDepartment of Gynaecology, OLVG Hospital, Amsterdam, Netherlands.
Julia ErnstDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Blandine FrenchSchool of Psychology, University of Nottingham, Nottingham, United Kingdom.
Matilda A FrickDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Cédric GaleraUniversity of Bordeaux, INSERM, BPH, U1219, Bordeaux, France.
Annabeth P GroenmanResearch Institute of Child Development and Education, University of Amsterdam, Amsterdam, Netherlands.
Helena Kopp KallnerDepartment of Clinical Sciences, Danderyd Hospital Karolinska Institutet, Stockholm, Sweden.
Julia Kerner Auch KoernerInstitute for Psychology in Education, University of Münster, Münster, Germany.
Sarah Kittel-SchneiderDepartment of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
Iris ManorADHD Clinic, Geha Mental Health Center, Petach-Tiqva, Israel.
Joanna MartinCentre for Neuropsychiatric Genetics and Genomics & Wolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, United Kingdom.
Emilia MateraDepartment of Precision and Regenerative Medicine and Ionic Area, University of Bari, Bari, Italy.
Valeria ParlatiniChild and Adolescent Psychiatry, University of Southampton/Hampshire, Southampton, United Kingdom.
Alexandra PhilipsenDepartment of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Josep Anthoni Ramos-QuirogaGroup of Psychiatry, Mental Health and Addictions, Vall D'Hebron Research Institute (VHIR), Biomedical Research Networking Centre Consortium on Mental Health (CIBERSAM), Barcelona, Spain.
Iris L RapoportResearch Institute of Child Development and Education, University of Amsterdam, Amsterdam, Netherlands.
Karl Lundin RemnéliusCenter of Neurodevelopmental Disorders (KIND), Department of Women's and Children's Health, Centre for Psychiatry Research, Karolinska Institutet & Region Stockholm, Stockholm, Sweden.
Amandine SénéquierDepartment of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.
Lisa ThorellDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Janneke M E WittekoekHeartLife Clinics Utrecht, Utrecht, Netherlands.
Dora WynchankExpertise Center Adult ADHD, PsyQ, Psycho-medical Programs, The Hague, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Attention-Deficit/Hyperactivity Disorder (ADHD) in girls and women is under-recognised and under-researched, despite increasing awareness of clinical challenges and unmet needs. This review by the Eunethydis Special Interest Group on Female ADHD, addresses current knowledge and identifies research gaps for future work. Issues in women with ADHD across the lifespan such as late diagnosis, pubertal development, sexual health, hormonal birth control, executive function difficulties, and gynaecological disorders associated with ADHD are highlighted. Methods: The review synthesises existing literature and self-reported experiences of women with ADHD to explore the impact of hormonal fluctuations [puberty, menstrual cycle, pregnancy, (peri)menopause] on ADHD symptoms and mood disturbances. It examines the interplay of oestrogen and progesterone with dopaminergic pathways, when periods of lower oestrogen may affect cognition, as well as the manifestation of executive function deficits, and the intersection of ADHD with reproductive health. Results: Hormonal transitions exacerbate ADHD symptoms and mood disturbances, yet pharmacological research and tailored treatments are lacking. Executive function deficits manifest differently in girls and women with ADHD and are influenced by neuropsychological and neurobiological profiles. Diagnostic practices and sociocultural factors contribute to delayed diagnoses, increasing the risk of comorbidities, impaired functioning, and diminished quality of life. Undiagnosed women have increased vulnerability to premenstrual dysphoric disorder, postpartum depression, and cardiovascular disease during perimenopause. Discussion: Longitudinal, sex-specific studies incorporating hormonal status and lived experience are needed. Individualised interventions should be developed to address the unique needs of girls and women with ADHD. Addressing these gaps will advance more equitable diagnosis, management, and support for girls and women with ADHD, improving outcomes across the female lifespan.

Indexed as

ADHDconsensusfemalelifespanmenstrual cycleself-reported needssex hormonessex specific

Identifiers

PMID40692967
PMCPMC12277363

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.