ArticleFrontiers in microbiology2025
Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Background: While gut microbiota dysbiosis has been associated with thyroid disorders, its causal role in goiter pathogenesis remains unclear. We aimed to investigate whether specific gut microbial taxa causally influence goiter risk through the short-chain fatty acid (SCFA)-iodine-thyroid axis. Methods: We performed Mendelian randomization (MR) analysis using gut microbiota genome-wide association study (GWAS) data (MiBioGen consortium, Results: MR analysis identified 10 gut microbial taxa causally associated with goiter risk (all Conclusion: This study provides causal evidence that Bifidobacterium depletion may contribute to goiter development through SCFA-mediated impairment of NIS-dependent iodine uptake and thyroid hormone synthesis, highlighting the association of the "gut-thyroid axis" and laying the foundation for early prevention and therapeutic intervention of goiter.
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