ArticleInsect science2026
Maltase 1 regulates DENV2 infection and life history in Aedes aegypti.
Article in Insect science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Functional Analysis of Amino Acid Residues Responsible for Substrate Specificity of GH13_17 α‑Glucosidase fromACS omega · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Aedes aegypti is a primary vector for many significant human pathogens. Maltase 1 (MAL1), a key enzyme in carbohydrate metabolism, hydrolyzes maltose to release glucose, which participates in sugar metabolism. Currently, there are no studies on the involvement of MAL1 in the regulation of viral infections in arthropods. The expression of MAL1 in Ae. aegypti significantly decreases after DENV2 infection. In this study, we used CRISPR/Cas9 technology to generate a MAL1 knockout strain of Ae. aegypti. The absence of MAL1 significantly suppressed DENV2 replication and transmission throughout the infection process in mosquitoes. At the same time, it reduced the hatching and pupation rates but increased the emergence rate. The absence of MAL1 extended the survival time of male Ae. aegypti while reducing the survival time of females. The results indicate that MAL1 affects arbovirus replication, transmission, and various stages of the Ae. aegypti life cycle.
Indexed as
Identifiers
40693397What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.