Evidence map›Paper›PMID 40693467›Full record

ArticleJCI insight2025

VEGFD/VEGFR2 axis induces the dedifferentiation of high endothelial venules and impairs lymphocyte homing.

Weichang Yang, Juan Wu, Shanshan Cai, Hongquan Xing, Jiajia Xiang, Xinyi Zhang, Xiaoyan Su, Xiaoqun Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weichang YangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, JiangxiMedical College, Nanchang University, Nanchang, Jiangxi, China.
Juan WuDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, JiangxiMedical College, Nanchang University, Nanchang, Jiangxi, China.
Shanshan CaiDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, JiangxiMedical College, Nanchang University, Nanchang, Jiangxi, China.
Hongquan XingDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, JiangxiMedical College, Nanchang University, Nanchang, Jiangxi, China.
Jiajia XiangJiangxi Key Laboratory of Molecular Medicine, Nanchang, Jiangxi, China.
Xinyi ZhangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, JiangxiMedical College, Nanchang University, Nanchang, Jiangxi, China.
Xiaoyan SuDepartment of Pathology, The Second Affiliated Hospital of Nanchang University, Jiangxi, Medical College, Nanchang University, Nanchang, Jiangxi, China.
Xiaoqun YeDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, JiangxiMedical College, Nanchang University, Nanchang, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High endothelial venules (HEVs) are important structures in lymph nodes (LNs) that mediate lymphocyte homing, and their dedifferentiation is a necessary step before LN metastasis. Whether vascular endothelial growth factor-related (VEGF-related) signaling, which plays an important role in LN metastasis, is involved in the dedifferentiation of HEVs remains unclear. Here, we confirmed increased expression of VEGFA, VEGFC, and VEGFD; HEV dedifferentiation; and impaired lymphocyte homing function in tumor-draining LNs (TDLNs). Furthermore, we demonstrated that tumor-secreted VEGFA induced lymphangiogenesis in TDLNs to promote premetastatic niche (PMN) formation; VEGFC promoted HEV proliferation but did not affect its lymphocyte homing function. Notably, we showed that VEGFD induced the dedifferentiation of HEVs by binding to VEGFR2 on the endothelial surface of HEVs and further impaired the lymphocyte homing function of TDLNs. Overall, we revealed that tumor-secreted VEGFD interacted with VEGFR2, induced HEV dedifferentiation, and reduced lymphocyte homing, providing potential insights for the prevention and treatment of LN metastasis.

Indexed as

LymphocytesVascular Endothelial Growth Factor DVascular Endothelial Growth Factor Receptor-2AnimalsCell DedifferentiationFemaleHumansLymphangiogenesisLymphatic MetastasisLymph NodesMiceMice, Inbred C57BLSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor CVenulesKdr protein, mouseVascular Endothelial Growth Factor AVascular Endothelial Growth Factor CVascular Endothelial Growth Factor DVascular Endothelial Growth Factor Receptor-2CancerImmunologyLymphPulmonology

Identifiers

PMID40693467
PMCPMC12288975

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.