Evidence map›Paper›PMID 40693601›Full record

ArticlebioRxiv : the preprint server for biology2025

Identifying out-of-voxel echoes in edited MRS with phase cycle inversion.

Zahra Shams, Abdelrahman Gad, Aaron T Gudmundson, Saipavitra Murali-Manohar, Christopher W Davies-Jenkins, Gizeaddis L Simegn, Dunja Simicic, Yulu Song, Vivek Yedavalli, Helge J Zöllner and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Zahra ShamsThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-0311-0665
Abdelrahman GadThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aaron T GudmundsonThe Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-5104-0959
Saipavitra Murali-ManoharThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christopher W Davies-JenkinsThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gizeaddis L SimegnThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dunja SimicicThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yulu SongThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vivek YedavalliThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Helge J ZöllnerThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7148-292X
Georg OeltzschnerThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3083-9811
Richard A E EddenThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Richard Anthony Edward Edden · 2021 to 2026
$9.9M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Edited Magnetic Resonance Spectroscopy of the Pediatric BrainR01EB032788 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2023 to 2026
$2.7M
Model Selection for Magnetic Resonance SpectroscopyR01EB035529 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Georg Oeltzschner · 2024 to 2026
$1.7M
General Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670k
Brain metabolism across the lifespan using multi-parametric MRSK99AG080084 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZOELLNER, HELGE JOERN · 2023 to 2024
$212k
NIA NIH HHS K99 AG080084NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIBIB NIH HHS R01 EB032788NIBIB NIH HHS R01 EB035529NIBIB NIH HHS R21 EB033516
6 · The paper itself

Abstract

Purpose: To identify the origin of out-of-voxel (OOV) signals based on the coherence transfer pathway (CTP) formalism using signal phase conferred by the acquisition phase cycling scheme. Knowing the CTP driving OOV artifacts enables optimization of crusher gradients to improve their suppression without additional data acquisition. Theory and Methods: A phase cycle systematically changes the phase of RF pulses across the transients of an experiment, encoding phase shifts into the data that can be used to suppress unwanted CTPs. We present a new approach, Results: The simulation results demonstrated that PCI can fully separate signals originating from different CTPs using a complete phase cycling scheme. PCI effectively identified the CTP responsible for OOV signals in phantom experiments and Conclusion: PCI can be broadly applied across pulse sequences and voxel locations, making it a flexible and generalizable approach for diagnosing the CTP origin of OOV signals.

Indexed as

coherence transfer pathwaysEdited MRSgradient schemeout-of-voxel artifactsphase cycling

Identifiers

PMID40693601
PMCPMC12262216

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.