Evidence map›Paper›PMID 40694181›Full record

ReviewNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation2025

Initial experience with combined heart-liver transplantation in the Netherlands: Exploring the boundaries of isolated and combined transplantation.

Ryan E Accord, Frans J C Cuperus, Elke Hoendermis, Massimo Mariani, Gianclaudio Mecozzi, Maarten W Nijkamp, Vincent E de Meijer, Joost M Klaase, Hans Blokzijl, Meine H Fernhout and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Advancing cardiovascular care-key insights from the Netherlands Heart Journal 2025.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ryan E AccordDepartment of Cardiothoracic Surgery, Centre for Congenital Heart Disease, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. r.e.accord@umcg.nl.ORCID http://orcid.org/0000-0003-0025-8522
Frans J C CuperusDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Elke HoendermisDepartment of Cardiology, Centre for Congenital Heart Disease, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Massimo MarianiDepartment of Cardiothoracic Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Gianclaudio MecozziDepartment of Cardiothoracic Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Maarten W NijkampDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Vincent E de MeijerDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Joost M KlaaseDepartment of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Hans BlokzijlDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Meine H FernhoutDepartment of Anesthesiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Koen M E M ReyntjensDepartment of Anesthesiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Joost M A A van der MaatenDepartment of Anesthesiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Marije SmitDepartment of Intensive Care, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
J DrooghDepartment of Intensive Care, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Michiel E ErasmusDepartment of Cardiothoracic Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Kevin DammanDepartment of Cardiology, Centre for Congenital Heart Disease, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Joost P van MelleDepartment of Cardiology, Centre for Congenital Heart Disease, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart transplantation is considered as the ultimate treatment for patients with advanced heart failure (HF). Chronic HF is associated with hepatic congestion and reduced cardiac output, which can lead to progressive liver disease. This issue is particularly relevant in patients with congenital heart disease, especially those with a single functional ventricle managed through Fontan-type surgery. The presence of advanced liver disease may contraindicate isolated heart transplantation and thus require consideration of combined heart-liver transplantation (CHLT). However, consensus criteria for CHLT have not yet been established. To illustrate the clinical and scientific discussions on this topic, we present the clinical course of two patients with a Fontan circulation who were evaluated for CHLT and discuss decision-making factors based on a review of current literature. We conclude that establishing a CHLT program represents a promising therapeutic pathway for patients in the Netherlands with advanced HF and concomitant liver disease. Both isolated heart transplantation and CHLT are viable treatment approaches for carefully selected patients with HF and liver disease. However, early identification of potential candidates and timely referral for a comprehensive evaluation are essential for the effective management of this high-risk patient group.

Indexed as

Congenital heart diseaseFontan-associated liver diseaseFontan failureHeart-liver transplantationHeart transplantation

Identifiers

PMID40694181
PMCPMC12364779

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.