Evidence map›Paper›PMID 40695287›Full record

ArticleDevelopmental cell2025

Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett's Esophagus to adenocarcinoma.

Michael K Strasser, David L Gibbs, Philippe Gascard, Joanna Bons, John W Hickey, Deng Pan, Joseph A Caruso, Xianhong Wang, Chira Chen-Tanyolac, Rosemary Bai and 32 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Biomarker Use in Barrett's Esophagus Surveillance.The American journal of gastroenterology · 2026
    Review
  3. Review
  4. Article
  5. MORPHE: Bridging Image Generation and Spatial Omics for Tissue Synthesis.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Michael K StrasserInstitute for Systems Biology, Seattle, WA 98109, USA.
David L GibbsInstitute for Systems Biology, Seattle, WA 98109, USA.
Philippe GascardDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Joanna BonsThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
John W HickeyDepartment of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27705, USA.
Deng PanDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Joseph A CarusoDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Xianhong WangDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Chira Chen-TanyolacDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Rosemary BaiDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Christian M SchürchDepartment of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology and Neuropathology, University Hospital and Comprehensive Cancer Center Tübingen, Tübingen 72076, Germany; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, 72076 Tübingen, Germany.
Yuqi TanDepartment of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Sarah BlackDepartment of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Pauline ChuDepartment of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alican OzkanWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02215, USA.
Nathan BasistyThe Buck Institute for Research on Aging, Novato, CA 94945, USA; National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Veena SangwanDivision of Thoracic and Upper Gastrointestinal Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
Jacob RoseThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Samah ShahThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Jordan B BurtonThe Buck Institute for Research on Aging, Novato, CA 94945, USA.
Sophie Camilleri-BroetDivision of Pathology, McGill University Health Center, Montreal, QC H4A 3J1, Canada.
Pierre Olivier FisetDivision of Pathology, McGill University Health Center, Montreal, QC H4A 3J1, Canada.
Nicholas BertosDivision of Thoracic and Upper Gastrointestinal Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
Julie BerubeDivision of Thoracic and Upper Gastrointestinal Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
Haig DjambazianMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canada.
Rui LiMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canada.
Spyridon OikonomopoulosMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canada.
Daffolyn Rachael Fels ElliottDepartment of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Sarah VernovskyWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02215, USA.
Elee ShimshoniWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02215, USA.
Deborah CollyarPatient Advocates in Research, Danville, CA 94506, USA.
Ann RussellNational Cancer Research Institute, London E20 1JQ, UK.
Jiannis RagoussisMcGill Genome Centre, Victor Phillip Dahdaleh Institute of Genomic Medicine, Department of Human Genetics, McGill University, Montreal, QC H3A 0G1, Canada; Department of Bioengineering, Mcgill University, Monreal, QC H3A 0E9, Canada.
Matthew D StachlerDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
James R GoldenringNashville VA Medical Center and Section of Surgical Sciences, Department of Cell and Developmental Biology, Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Stuart A C McDonaldCentre for Cancer Evolution, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Donald E IngberWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02215, USA; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA. Electronic address: don.ingber@wyss.harvard.edu.
Birgit SchillingThe Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: bschilling@buckinstitute.org.
Garry P NolanDepartment of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: gnolan@drowlab.com.
Thea D TlstyDepartment of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: thea.tlsty@ucsf.edu.
Sui HuangInstitute for Systems Biology, Seattle, WA 98109, USA. Electronic address: sui.huang@isbscience.org.
Lorenzo E FerriDivision of Thoracic and Upper Gastrointestinal Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, QC H3G 1A4, Canada. Electronic address: lorenzo.ferri@mcgill.ca.

Funding

Plastic States Associated with Cellular Stress and Malignancy: Insights for Prevention and Treatment of Lethal Metaplastic CancersR35CA197694 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TLSTY, THEA D · 2016 to 2022
$6.1M
RESEARCH TRAINING IN NEPHROLOGYT32DK007199 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI POLLAK, MARTIN R. · 1986 to 2022
$6.0M
Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagusR37CA269649 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthew D Stachler · 2023 to 2026
$2.6M
Theory and Measurement of Cell Population Dynamics with Cell-Cell Interaction (TMCC)R01GM135396 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI HUANG, SUI · 2019 to 2022
$1.7M
Defining a Stromal Signature that Facilitates Progression of Lethal CancersR50CA211543 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GASCARD, PHILIPPE · 2019 to 2023
$1.2M
TripleTOF 5600 High Resolution Mass SpectrometerS10OD016281 · OD · BUCK INSTITUTE FOR RESEARCH ON AGING · PI GIBSON, BRADFORD WAYNE · 2013 to 2013
$597k
NCI NIH HHS R35 CA197694NCI NIH HHS R37 CA269649NCI NIH HHS R50 CA211543NIDDK NIH HHS T32 DK007199NIGMS NIH HHS R01 GM135396NIH HHS S10 OD016281
6 · The paper itself

Abstract

Esophageal adenocarcinoma arises from Barrett's esophagus, a metaplastic condition. Multi-omics profiling, integrating single-cell transcriptomics, extracellular matrix proteomics, tissue mechanics and spatial proteomics of the paths of progression from squamous epithelium through metaplasia, dysplasia to adenocarcinoma, in 107 samples from 26 patients in two independent cohorts, defined shared and patient-specific progression characteristics. Metaplastic replacement of epithelial cell composition and architecture was paralleled by changes in stromal cells, extracellular matrix (ECM) and tissue stiffness. This change in pre-cancerous metaplasia was already accompanied by appearance of fibroblasts with the molecular characteristics of carcinoma-associated fibroblasts. These fibroblasts produced the immunosuppressive protein POSTN, whose expression shifted from vascular to stromal cells, consistent with the emergence of an immunosuppressive microenvironment evident in cell neighborhoods enriched for immunoregulatory NK and Treg cells. Thus, Barrett's esophagus progresses as a coordinated multi-component system, supporting treatment paradigms that go beyond targeting cancerous cells to incorporate stromal reprogramming.

Indexed as

AdenocarcinomaBarrett EsophagusEsophageal NeoplasmsStromal CellsDisease ProgressionEpithelial CellsEpitheliumExtracellular MatrixFemaleFibroblastsHumansMaleMultiomicsProteomicsTranscriptomeTumor MicroenvironmentBarrett’s esophagusCODEXcopy number variationECM proteomicsesophageal adenocarcinomametaplasiascRNA-seq

Identifiers

PMID40695287
PMCPMC12327839

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.