Evidence map›Paper›PMID 40695403›Full record

ReviewJournal of advanced research2026

Biological potential and mechanisms of Brain-Expressed X-linked family proteins in cancers: an updated review.

Pingping Wang, Ziyan Chen, Hongyan Zhang, Yandan Lu, Licheng Zhou, Chenghang Gong, Dongyang An, Xianan Sang, Kuilong Wang, Min Hao and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pingping WangSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China; Zhejiang Cancer Hospital, Hangzhou, 310022, China.
Ziyan ChenSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Hongyan ZhangZhejiang Cancer Hospital, Hangzhou, 310022, China.
Yandan LuSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Licheng ZhouSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Chenghang GongSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Dongyang AnSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Xianan SangSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Kuilong WangSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Min HaoSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: hao_min0509@163.com.
Gang CaoSchool of Pharmaceutical Sciences, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: caogang33@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrain-Expressed X-linked (BEX) family proteins is a relative younger protein family in human being, with limited understanding of its pathophysiological functions in health and disease. So far, The human BEX family consists of five members including BEX1-5, which have highly homologous and different subcellular localization, expression patterns and proteasome degradation. Previous research found that BEX family proteins play an important role in p75NTR signal pathway which closely connected with neuron differentiation and regeneration. In recent ten years, more and more studies have shown that BEX family proteins participate in multiple molecular signaling pathways in cancers, liver diseases, heart diseases et al. These evidences hint that BEX family proteins maybe potential therapeutic targets for multiple diseases. AIM OF REVIEW: In this review, we systematically summarize the research progress on the role of BEX family proteins in patients with various cancers. Our goal is to provide new treatments and insights into human cancers. In addition, the underlying mechanisms and potential clinical applications of BEX family proteins involved in various cancers were highlighted. KEY SCIENTIFIC CONCEPTS OF REVIEW: The BEX family proteins plays an important role in a variety of biological processes, including inhibiting the proliferation and metastasis of cancer cells, and participating in various biological processes such as cell differentiation, cell proliferation, and cell apoptosis.

Indexed as

NeoplasmsAnimalsCell DifferentiationCell ProliferationHumansSignal TransductionAction mechanismBEX family proteinsDisease and cancerSignal pathTreatment strategy

Identifiers

PMID40695403
PMCPMC13001068

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.