Evidence map›Paper›PMID 40695641›Full record

ReviewTrends in neurosciences2025

A functional perspective on astrocyte heterogeneity.

Wookbong Kwon, Michael R Williamson, Benjamin Deneen

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Cerebellar astrocytic alterations in depression.Translational psychiatry · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wookbong KwonCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Michael R WilliamsonCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Benjamin DeneenCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. Electronic address: deneen@bcm.edu.

Funding

Astrocyte Transcriptional Dependencies in Brain CircuitsR35NS132230 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin Deneen · 2023 to 2026
$3.5M
Defining Roles for Astrocyte Subpopulations in the Aging BrainR01AG071687 · NIA · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2021 to 2025
$2.0M
Defining Astrocyte Engram Ensembles During Memory FormationR21MH134002 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN · 2023 to 2023
$440k
NIA NIH HHS R01 AG071687NIMH NIH HHS R21 MH134002NINDS NIH HHS R35 NS132230
6 · The paper itself

Abstract

Astrocytes are glial cells of the central nervous system (CNS) that perform an array of diverse functions that are essential for brain activity. Studies on the functional diversity of astrocytes suggest that such diversity may be derived from specialized populations. We provide an overview of the current state of research on astrocyte diversity and outline current challenges and knowledge gaps while also examining the developmental origins of these populations and how their interactions with neurons contribute to their functional heterogeneity. We highlight recent studies that provide evidence for functionally diverse astrocyte populations under homeostatic conditions and as an adaptive response to a range of experiences. This review provides a framework for understanding the dynamic and heterogeneous features of astrocytes across the CNS.

Indexed as

AstrocytesCentral Nervous SystemAnimalsBrainHumansNeuronsadaptationbraincellular diversitydevelopmenthomeostasisneural circuit

Identifiers

PMID40695641
PMCPMC12313154

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.