Evidence map›Paper›PMID 40695874›Full record

ArticleScientific reports2025

Exploring thoracic aorta ECM alterations in Marfan syndrome: insights into aorta wall structure.

Rodrigo Barbosa de Souza, Luara Lucena Cassiano, Philipp Barnowski, Sara Ventura, Walter Miguel Turato, Suelen Cristina Russafa Nascimento, Giovanna Lodi Mignanelli, Waldir Caldeira, Ana Maria Cristina Rebelo Pinto da Fonseca Martins, Flavio de Carvalho Luposeli and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Integrin Signaling Pathways in Aortic Aneurysm and Dissection.Reviews in cardiovascular medicine · 2026
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rodrigo Barbosa de SouzaDepartment of Descriptive and Topographic Anatomy, Faculty of Santa Marcelina, São Paulo, Street Santa Marcelina, 91, 08270-140, SP, Brazil. rodrigo.bsouza@santamarcelina.edu.br.
Luara Lucena CassianoAquaculture Research and Development Center (CPDA), Fishing Institute of São Paulo, São Paulo, 04014-002, SP, Brazil.
Philipp BarnowskiDepartment of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Sara VenturaVascular Biology Laboratory, The Heart Institute, University of Sao Paulo School of Medicine, São Paulo, 05403-000, SP, Brazil.
Walter Miguel TuratoDepartment of Clinical and Toxicological Analysis, University of São Paulo, São Paulo, 05508-000, SP, Brazil.
Suelen Cristina Russafa NascimentoLaboratory of Genetics and Molecular Cardiology, The Heart Institute, University of Sao Paulo School of Medicine, São Paulo, 05403-000, SP, Brazil.
Giovanna Lodi MignanelliDepartment of Descriptive and Topographic Anatomy, Faculty of Santa Marcelina, São Paulo, Street Santa Marcelina, 91, 08270-140, SP, Brazil.
Waldir CaldeiraDepartment of Genetics and Evolutionary Biology, University of São Paulo, São Paulo, 05508-090, SP, Brazil.
Ana Maria Cristina Rebelo Pinto da Fonseca MartinsDepartment of Animal Sanity, Biologic Institute of São Paulo, São Paulo, 04014-002, SP, Brazil.
Flavio de Carvalho LuposeliDepartment of Surgery, Federal University of São Paulo, São Paulo, 04039-032, SP, Brazil.
Francisco Rafael Martins LaurindoVascular Biology Laboratory, The Heart Institute, University of Sao Paulo School of Medicine, São Paulo, 05403-000, SP, Brazil.
Dieter P ReinhardtFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Gerhard SengleDepartment of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.
Ivan Hong Jun KohDepartment of Clinical and Toxicological Analysis, University of São Paulo, São Paulo, 05508-000, SP, Brazil.
Keith M MeekStructural Biophysics Research Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, CF24 4HQ, UK.
Philip N LewisStructural Biophysics Research Group, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cathays, Cardiff, CF24 4HQ, UK. lewispn@cardiff.ac.uk.

Funding

CEPID Redoxoma Network, supported by Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/07937-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.899440/2023-00Deutsche Forschungsgemeinschaft 397484323 [TRR259/B09]Fundação de Amparo à Pesquisa do Estado de São Paulo 001Genetic Aortic Disorders Association Canada Gada Canada Aortic Research Grant AwardMedical Research Council MR/S037829/1
6 · The paper itself

Abstract

Marfan syndrome is a connective tissue disorder caused by FBN1 mutations, leading to aortic wall fragility and increased susceptibility to aneurysm and dissection. This study investigated microstructural and molecular alterations in the thoracic aorta of Fbn1mgΔ

Indexed as

Aorta, ThoracicExtracellular MatrixMarfan SyndromeAdipokinesAnimalsDisease Models, AnimalElastic TissueFibrillin-1MaleMiceTunica IntimaAdipokinesFbn1 protein, mouseFibrillin-1AneurysmAortaCollagenExtracellular matrixFibrillin-1Marfan syndrome

Identifiers

PMID40695874
PMCPMC12284111

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.