Evidence map›Paper›PMID 40695945›Full record

ArticleScientific reports2025

Impact of mannitol on mortality in patients with non-traumatic intracerebral haemorrhage and acute kidney injury: a retrospective study.

Weixiao Chen, Qingzhou Chen, Yuli Wang, Qilin Yang, Weiyan Chen, Lili Tao, Jiezhao Zheng, Deliang Wen, Zhenhui Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weixiao Chen *Department of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Qingzhou Chen *Department of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Yuli WangDepartment of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Qilin YangDepartment of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Weiyan ChenDepartment of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Lili TaoDepartment of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Jiezhao ZhengDepartment of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Deliang WenDepartment of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. deliangw@163.com.
Zhenhui ZhangDepartment of Intensive Care Unit, Guangzhou Key Laboratory of Prevention and Treatment of Multiple Organ Dysfunction Syndrome, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. zhzhhicu@126.com.

Funding

The National Natural Science Foundation of China 82202371The Natural Science Foundation of Guangdong Province 2022A1515010397
6 · The paper itself

Abstract

Mannitol is widely used for treating brain edema caused by various diseases, but it has been reported to cause acute kidney injury. However, the prognosis for patients with non-traumatic intracerebral hemorrhage who also have acute kidney injury and continue to receive mannitol has not yet been documented. This study presents a retrospective cohort analysis utilizing the MIMIC-IV (medical information mart for intensive care-IV) database. The study population comprised adult patients diagnosed with non-traumatic intracerebral hemorrhage (ICH) and concurrent acute kidney injury (AKI). Mannitol administration during the intensive care unit (ICU) stay was considered the exposure variable. The primary endpoint for analysis was 28-day all-cause mortality. To account for potential confounding factors, multivariable analytical methods were employed. The 28-day mortality rate within the total cohort was 25%. In the mannitol group, the 28-day mortality rate was 50.4% (58/115), compared to 21.9% (203/927) in the control group. Mannitol use was associated with a significantly higher 28-day all-cause mortality in both the multivariable analysis (HR 2.42; 95% CI 1.80-3.25; p < 0.001) and the univariable analysis (HR 2.31; 95% CI 1.67-3.19; p < 0.001). Other variables independently associated with mortality included higher heart rate, mean arterial pressure, respiratory rate, platelet count, sodium, chloride, lactate, urea nitrogen, creatinine, SAPSII, SOFA, GCS, and Charlson Index. The in-hospital mortality rate was 47.8% (55 out of 115) in the mannitol treatment group and 16.2% (150 out of 927) in the non-treatment group. Mannitol use was associated with higher 28-day all-cause mortality in patients with non-traumatic ICH and AKI. However, given the methodological limitations and incomplete confounder adjustment of this study, this finding should be interpreted with caution. Further research is needed to confirm this relationship and explore the underlying mechanisms.

Indexed as

Acute Kidney InjuryCerebral HemorrhageMannitolAdultAgedAged, 80 and overDiuretics, OsmoticFemaleHumansIntensive Care UnitsMaleMiddle AgedRetrospective StudiesDiuretics, OsmoticMannitolAKIDeathICHMannitolMIMIC-IV

Identifiers

PMID40695945
PMCPMC12284147

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.