ArticleBMC infectious diseases2025
Factors associated with post-treatment resorption of lung cavities in individuals with first episodes of drug-sensitive cavitary pulmonary tuberculosis in China.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Analysis of Drug Resistance Characteristics and Risk Factors of Cavitary Tuberculosis Based on Whole Genome Sequencing and Machine Learning.Open forum infectious diseases · 2026Article
- Risk Factors and Prediction of Chronic Obstructive Pulmonary Disease After Pulmonary Tuberculosis: A Prospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundIn patients with pulmonary tuberculosis (TB), the persistence of the lung cavities leads to opportunistic infections and increases the risk of person-to-person Mycobacterium tuberculosis (Mtb) transmission. However, factors that associated with cavity resorption remain unknown.
methodsIn this retrospective study, 588 patients with drug-sensitive pulmonary tuberculosis and cavitary lesions on chest imaging were enrolled. All patients completed a standard 6-month anti-tuberculosis drug treatment regimen. They were randomly divided into a training set (n = 412) and a validation set (n = 176) in a 7:3 ratio. Clinical variables including demographic data, radiological findings, laboratory test results, and anti-tuberculosis drug usage were collected. Univariate and multivariate logistic regression analyses were performed to identify factors associated with cavity absorption.
resultsMultivariate logistic regression identified several factors independently associated with poor cavity resorption: older age (odds ratio [OR] 1.029, 95% confidence interval [CI]: 1.012-1.047), male sex (OR 2.599, CI: 1.349-5.009), serum total protein (OR 0.963, CI: 0.931-0.997), presence of multiple cavities (OR 1.791, CI: 1.115-2.876) and absence of fever (OR 1.729, CI: 1.032-2.893). The predictive model constructed using these six variables showed good discrimination, with an area under the curve (AUC) of 0.749 (95% CI: 0.699-0.798) in the training set and 0.746 (95% CI: 0.670-0.822) in the validation set (n = 176).
conclusionsOur findings indicate that older age, male sex, lower serum total protein, presence of multiple cavities, and absence of fever are independently associated with poor cavity resorption in patients with pulmonary tuberculosis. These variables may help identify high-risk patients and guide personalized management. Therefore, for better control of Mtb infection and improved outcomes, greater clinical attention should be paid to these associated factors.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.