Evidence map›Paper›PMID 40696451›Full record

ArticleEuropean journal of medical research2025

Untargeted metabolomics-based elucidation of metabolic reprogramming mechanisms and pathways following aortic dissection surgery.

Jun He, Yuji Xiao, Wanru Ma, Yaoguang Feng, Chengming Ding, Haonan Zhang, Heng Yang, Zhengwen Lei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jun He *Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Yuji Xiao *Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Wanru MaDepartment of Dermatology, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Yaoguang FengDepartment of Cardiothoracic and Vascular Surgery, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Chengming DingDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Haonan ZhangDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Heng YangDepartment of Cardiothoracic and Vascular Surgery, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Zhengwen LeiDepartment of Cardiothoracic and Vascular Surgery, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. leizhengwen0803@163.com.

Funding

Department of Science and Technology of Hunan Province 2021SK51802Education Department of Hunan Province HNJG-20230600Natural Science Foundation of Hunan Province 2023JJ50152
6 · The paper itself

Abstract

backgroundPostoperative complications persist in acute DeBakey type I aortic dissection (AD) despite surgical advances, yet the underlying metabolic mechanisms remain unexplored. This knowledge gap critically limits targeted interventions.

methodsUntargeted metabolomics using ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) was performed on 90 serum samples, including: preoperative AD patients (n = 30), postoperative samples from the same cohort (AT group, n = 30), and healthy controls (HC, n = 30). Multivariate statistics through orthogonal partial least squares-discriminant analysis (OPLS-DA) identified differential metabolites (variable importance in projection [VIP] > 1, P < 0.05), with Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment revealing regulatory networks.

resultsThree interconnected mechanisms were identified: Lipid homeostasis remodeling was characterized by activated linoleic acid metabolism (P = 0.0136), which elevated anti-inflammatory epoxy-eicosatrienoic acids (EETs) and suppressed nuclear factor-kappa B (NF-κB) signaling; Energy reprogramming: Pyruvate/tricarboxylic acid (TCA) cycle intermediates synergized with arginine/nitric oxide (NO) pathway to scavenge reactive oxygen species (ROS).

conclusionsWe propose a multifaceted regulatory network centered on lipid remodeling, energy adaptation, and antioxidant defense, providing a multitarget framework for mitigating postoperative complications in AD.

Indexed as

Aortic DissectionMetabolomicsPostoperative ComplicationsAgedFemaleHumansLipid MetabolismMaleMetabolic Networks and PathwaysMetabolic ReprogrammingMiddle AgedAcute DeBakey Type I Aortic DissectionEnergy metabolism optimizationLipid homeostasis remodelingMetabolic reprogrammingOxidative defense networkPathway crosstalkUntargeted metabolomics

Identifiers

PMID40696451
PMCPMC12281785

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.