Evidence map›Paper›PMID 40696523›Full record

ArticleJournal of Korean medical science2025

Clinical Characteristics and Epidemiology of Cardiovascular Autonomic Neuropathy in Peoples With Long-Standing Diabetes.

Sook Jung Lee, Chong Hwa Kim, Su Jin Jeong, Jae-Seung Yun, Jong Chul Won, Jae Hyuk Lee, Ie Byung Park, Chang Won Lee, Hyuk-Sang Kwon, Tae Sun Park

Abstract readMulticenter Study
In one paragraph

Article in Journal of Korean medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sook Jung Lee *Division of Endocrinology and Metabolism, Department of Internal Medicine, Incheon Sejong General Hospital, Incheon, Korea.ORCID https://orcid.org/0000-0001-9305-7265
Chong Hwa Kim *Division of Endocrinology and Metabolism, Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea.ORCID https://orcid.org/0000-0002-4563-7772
Su Jin JeongDivision of Endocrinology and Metabolism, Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea.ORCID https://orcid.org/0000-0002-4125-0992
Jae-Seung YunDivision of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-5949-1826
Jong Chul WonDivision of Endocrinology and Metabolism, Department of Internal Medicine, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2219-4083
Jae Hyuk LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University, Goyang, Korea.ORCID https://orcid.org/0000-0001-5453-9480
Ie Byung ParkDivision of Endocrinology and Metabolism, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.ORCID https://orcid.org/0000-0003-0194-1665
Chang Won LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Busan St. Mary's Hospital, Busan, Korea.ORCID https://orcid.org/0000-0002-6184-7171
Hyuk-Sang KwonDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-4026-4572
Tae Sun ParkDivision of Endocrinology and Metabolism, Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Korea. pts@jbnu.ac.kr.ORCID https://orcid.org/0000-0001-7216-8468

Funding

Medicore
6 · The paper itself

Abstract

backgroundCardiovascular autonomic neuropathy (CAN) is a frequently underdiagnosed complication of diabetes mellitus that contributes to increased mortality and morbidity rates. This multicenter study investigated the epidemiology and clinical characteristics of CAN in patients with long-term diabetes.

methodsRetrospective data were collected from 884 individuals with diabetes who were assessed for CAN across eight hospitals in Korea. CAN was diagnosed using electrocardiography and cardiovascular autonomic function tests, including the heart rate-corrected QT interval and Ewing's method. This study evaluated the clinical characteristics, cardiovascular autonomic nerve function test results, and risk factors associated with CAN.

resultsAmong the 884 patients, 778 (88%) were diagnosed with CAN (DCAN), while 106 (12%) were not (non-DCAN). Individuals with DCAN were older, had a longer duration of diabetes, and had higher creatinine levels. The DCAN group showed decreased time and frequency parameters of heart rate variability (HRV). A multiple logistic regression analysis revealed that a longer diabetes duration, older age, and higher creatinine level were significant risk factors for CAN.

conclusionCAN was associated with advanced age, a longer duration of diabetes, higher creatinine levels, and lower time and frequency HRV parameters.

Indexed as

Autonomic Nervous System DiseasesCardiovascular DiseasesDiabetes Mellitus, Type 2Diabetic NeuropathiesAdultAgedAge FactorsCreatinineElectrocardiographyFemaleHeart RateHumansLogistic ModelsMaleMiddle AgedRepublic of KoreaCreatinineCardiovascular Autonomic NeuropathyEwing's MethodHeart Rate VariabilityLong-Duration DiabetesQTc Prolongation

Identifiers

PMID40696523
PMCPMC12284305

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.