Evidence map›Paper›PMID 40696603›Full record

ReviewMedicine2025

Application of blood flow restriction training in adolescents: A narrative review.

Zhen-Lei Chen, Tian-Shu Zhao, Shuang-Feng Ren, Si-Zhuo Zhang, Ji-Lai Xu, You-Qing Shen, Li-Ping Huang

Abstract readReview
In one paragraph

Review in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Blood Flow Restriction Training in Hemodialysis Patients: Clinical Benefits, Challenges, and Future Perspectives.Hemodialysis international. International Symposium on Home Hemodialysis · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhen-Lei ChenSchool of Physical Education, Hubei University of Education, Wuhan, Hubei Province, China.ORCID 0000-0001-5508-6428
Tian-Shu ZhaoCollege of Sports Medicine and Rehabilitation, Beijing Sports University, Beijing, China.
Shuang-Feng RenCollege of Sports Medicine and Rehabilitation, Beijing Sports University, Beijing, China.
Si-Zhuo ZhangCollege of Physical Education, International Equestrian school, Wuhan Business University, Wuhan, Hubei Province, China.
Ji-Lai XuGraduate School of Medicine, Juntendo University, Tokyo, Japan.
You-Qing ShenSchool of Physical Education, Hubei University of Education, Wuhan, Hubei Province, China.
Li-Ping HuangCollege of Sports Medicine and Rehabilitation, Beijing Sports University, Beijing, China.

Funding

Humanities and social science research Foundation of Ministry of Education of China 18YJC890032
6 · The paper itself

Abstract

Blood flow restriction training (BFRT) involves applying external compression to the limbs to restrict venous blood return during low-intensity exercise, thereby promoting improvements in muscle mass and strength. Originally developed decades ago, BFRT has gained renewed interest in recent years, with applications spanning rehabilitation medicine, aerospace, and general fitness. However, its use in adolescents remains limited and under-researched. This narrative review aims to summarize the current understanding of the effects, mechanisms, and practical applications of BFRT in adolescents, with a focus on muscle health, physical performance, and training safety. A comprehensive review of recent literature was conducted, focusing on BFRT-related physiological mechanisms, including metabolic stress, anabolic hormone responses, muscle fiber recruitment, protein synthesis regulation, myostatin suppression, and cell swelling. Relevant studies on adolescent populations were analyzed to evaluate the efficacy and safety of BFRT in this age group. BFRT appears to promote muscle hypertrophy, strength, endurance, and neuromuscular adaptations in adolescents, with reduced injury risk compared to high-load training. Individualized arterial occlusion pressure settings enhance both the safety and effectiveness of BFRT. Applications span general fitness, athletic performance enhancement, and injury rehabilitation. BFRT offers a promising, low-risk alternative to traditional resistance training for adolescents, supporting safe and effective physical development. Its integration into youth fitness and rehabilitation programs by educators, healthcare providers, and sports organizations may offer substantial benefits for adolescent health and performance.

Indexed as

Blood Flow Restriction TherapyMuscle, SkeletalAdolescentAthletic PerformanceHumansMuscle StrengthResistance Trainingadolescentsblood flow restriction traininglow-load exercisephysical healthstrength training

Identifiers

PMID40696603
PMCPMC12282689

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.