Evidence map›Paper›PMID 40696652›Full record

Trial reportMedicine2025

Effect of low-intensity pulsed ultrasound combined with aerobic exercise on patients with knee osteoarthritis: A randomized controlled study.

Huaichun Yang, Hongyu Liu, Ben Huang, Haodong Zhang, Xiaoyue Zhu, Kang Chen, Jie Shen, Yanping Qu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huaichun YangDepartment of Rehabilitation Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-7903-2985
Hongyu LiuDepartment of Rehabilitation Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ben HuangDepartment of Rehabilitation Medicine, Shanghai Eighth People's Hospital, Shanghai, China.
Haodong ZhangDepartment of Rehabilitation Medicine, Shanghai Eighth People's Hospital, Shanghai, China.
Xiaoyue ZhuDepartment of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kang ChenDepartment of Rehabilitation Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie ShenDepartment of Rehabilitation Medicine, Shanghai Eighth People's Hospital, Shanghai, China.
Yanping QuDepartment of Rehabilitation Medicine, Shanghai Eighth People's Hospital, Shanghai, China.

Funding

The Project of Shanghai Municipal Health Commission 20214Y0078
6 · The paper itself

Abstract

backgroundThe present study aimed to investigate whether the combination of low-intensity pulsed ultrasound (LIPUS) and aerobic exercise (AE) exerts an enhanced therapeutic benefit for patients with knee osteoarthritis.

methodsParticipants were allocated into a LIPUS treatment group, an AE treatment group, and a LIPUS combined with AE (LIPUS + AE) treatment group. Numerical rating scale (NRS) and Lequesne index were determined, and gait analysis was performed before treatment and after 12 weeks of treatment.

resultsThe LIPUS treatment could significantly alleviate NRS score and Lequesne index in patients with knee osteoarthritis. The AE treatment could significantly alleviate NRS score and Lequesne index, accompanied by improvement in stride length, stride speed, and total walking distance. LIPUS + AE treatment further contributed to an improvement in NRS score and Lequesne index, accompanied by improvement in stride length, stride speed, and total walking distance. At the end of treatment, the Lequesne index improvement on LIPUS + AE treatment group was greater than LIPUS or AE group, NRS score improvement on LIPUS + AE treatment group was greater than LIPUS group. The stride speed, stride length, and total walking distance improvements on LIPUS + AE treatment group were greater than either LIPUS or AE group.

conclusionThe study indicates LIPUS + AE treatment is more effective than LIPUS or AE for knee osteoarthritis. LIPUS + AE promises to be a potential rehabilitation therapy for patients with knee osteoarthritis.

Indexed as

ExerciseExercise TherapyOsteoarthritis, KneeUltrasonic TherapyAgedCombined Modality TherapyFemaleHumansMaleMiddle AgedTreatment Outcomeaerobic exercisekneelow-intensity pulsed ultrasoundosteoarthritis

Identifiers

PMID40696652
PMCPMC12282777

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.