SynthesisMedicine2025
Non-surgical treatment of cyclosporin A-induced gingival overgrowth: A systematic review and meta-analysis.
Synthesis in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Drug-induced gingival overgrowth: FAERS based real-world pharmacovigilance study and network pharmacology analysis.Frontiers in pharmacology · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclosporin A-induced (CsA-induced) gingival overgrowth (GO) is a common side effect affecting many patients. While surgical intervention is often considered the primary treatment, the effectiveness of nonsurgical periodontal therapy for CsA-induced GO remains unclear. This meta-analysis aimed to assess the efficacy of nonsurgical periodontal treatment in CsA-induced GO.
methodsArticles were retrieved from 7 databases (Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure, Chinese Academic Database, Clinical Trials Database, and Grey Literature Database) until November 5th, 2024. Randomized controlled trials (RCTs) or pre-post studies containing patients with GO caused by cyclosporine who received nonsurgical periodontal treatment were included. The protocol was published in International Prospective Register of Systematic Reviews with the ID CRD42024570280.
resultsA total of 13 studies were included. Five studies were RCTs comparing nonsurgical periodontal treatment groups and control groups among patients with GO; the other 8 studies were single group pre-post studies. Meta-analysis of RCTs demonstrated the hypertrophy index (standardized mean difference [SMD] = -1.14; 95% confidence intervals [CI]: [-1.59, -0.69]) and plaque index (SMD = -1.06, 95% CI: [-2.04, -0.07]) were significantly lower in the nonsurgical treatment groups than those in the control groups. Meta-analysis of single group pre-post studies showed that the levels of hypertrophy index (SMD = -1.49; 95% CI: [-2.92, -0.06]), probing depth (SMD = -1.52, 95% CI: [-2.46, -0.58]) and plaque index (SMD = -1.53, 95% CI: [-2.18, -0.88]) decreased significantly after treatment. Subgroup analyses indicated that antibiotics are important sources of heterogeneity.
conclusionThis meta-analysis supports the effectiveness of nonsurgical treatments for CsA-induced GO, and comprehensive pre and posttransplant oral care is recommended. Further studies are needed to determine the biological mechanisms and influence of each variable on the efficacy of nonsurgical treatments in reducing drug-induced GO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.