SynthesisAnnals of medicine2025
Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- RACGAP1 defines a malignant proliferative niche and represents a therapeutic vulnerability in lung adenocarcinoma.Translational lung cancer research · 2026Article
- Artemisinin exerts anti-inflammatory effects in osteoarthritis through the inhibition of TGF-β1 signaling.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe etiology of osteoarthritis (OA) remains unclear, involving a complex interaction of environmental and genetic factors. Observational studies have contributed substantially to identify modifiable risk factors that were associated with OA risk, but conclusions about the causality are hard to draw as these observed associations are susceptible to be interfered with reverse causality and residual confounding.
methodsMendelian randomization (MR) is a valid approach to provide evidence on causal associations, by using genetic variants as 'proxies' for modifiable exposures to examine the effect of genetic susceptibility to the exposures on the outcomes. Such a method provides an opportunity to elucidate OA pathogenesis and therefore to provide evidence for novel interventions and treatment strategies.
findingsIn this systematic review, we synthesized evidence from recent studies that applied MR in OA in terms of eight aspects, including lifestyle, nutrition, bone mineral density, reproductive factors, metabolic syndrome, cardiovascular disease, inflammation cytokines and other risk factors.
conclusionsWe reflected on the limitations of its current applications in OA, followed by a discussion of our findings and future directions in this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.