ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Dual-Targeted Nanovesicles Induced Cancer Stem-Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Targeting the Notch signaling pathway in digestive system cancers: from bench to bedside.Cancer cell international · 2026Review
- Epicatechin suppresses cancer stem-like cell phenotype and radioresistance in non-small cell lung cancer via targeting CXCL8.Biology direct · 2026Article
- Organoids for disease modeling and treatment: state-of-the-art.Experimental hematology & oncology · 2026Review
- Notch signaling in liver diseases: mechanistic insights and therapeutic implications.Frontiers in cell and developmental biology · 2026Review
- Dual-Targeted Nanovesicles Induced Cancer Stem-Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Highly plastic cancer stem-like cells (CSCs) in hepatocellular carcinoma (HCC) drive tumor heterogeneity, contributing to radiotherapy failure. Although inducing CSC differentiation is proven effective in leukemia, this approach is shown limited success in solid tumors due to the complex signaling networks that sustain CSC stemness. In this study, the synergistic effect of Pin1 and Notch1 in HCC is identified, which plays a pivotal role in maintaining the aggressiveness of CSCs and promoting radioresistance. Building on this discovery, biomimetic nanovesicles (CALT-GM-NVs) are engineered by infusing tumor cell membranes into liposomes, which exhibit superior binding affinity to CSCs. RNA sequencing reveals that CALT-GM-NVs downregulate oncogenic signaling pathways while upregulating those linked to differentiation and apoptosis. In vivo, CALT-GM-NVs significantly reduced CSC-driven radiotolerance and improved radiotherapy efficacy in both cell line-derived and patient-derived HCC xenograft models. These findings highlight the potential of simultaneously targeting Pin1 and Notch1 to induce CSC differentiation and provide a promising radiosensitizer for improving HCC radiotherapy outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.