Evidence map›Paper›PMID 40697155›Full record

ArticleMolecular and cellular biology2025

Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms.

Diana Saleiro, Jeremy Q Wen, Markella Zannikou, Brian Lee, Ewa M Kosciuczuk, Sarah D Nehlsen, Adam Munshi, Xintong Chen, Chidera V Oku, Briana Hryhorysak and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Diana SaleiroRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.ORCID 0000-0002-6756-3620
Jeremy Q WenDivision of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Markella ZannikouRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Brian LeeDivision of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Ewa M KosciuczukRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Sarah D NehlsenRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Adam MunshiRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Xintong ChenDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine Northwestern University, Chicago, Illinois, USA.
Chidera V OkuRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Briana HryhorysakRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Jamie N Guillen MagañaDivision of Hematology-Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Jorge HenecheRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Mariafausta FischiettiRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Liliana IlutRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Sara H SmallRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Anitria CottonDivision of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Trent HallDivision of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Monique A PaytonDivision of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Elspeth M BeauchampRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Feng YueRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Masha KocherginskyRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Elizabeth T BartomRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.
Ronald HoffmanMyeloproliferative Neoplasms Research Consortium, USA.
John D CrispinoDivision of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Leonidas C PlataniasRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.

Funding

Tumor Environment and MetastasisP30CA060553 · NORTHWESTERN UNIVERSITY · 1993 to 2025
$31.0M
Project 4: MPN Clinical ConsortiumP01CA108671 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$4.0M
CARCINOGENESIS TRAINING PROGRAMT32CA009560 · NORTHWESTERN UNIVERSITY · 1986 to 2025
$2.2M
SIGNAL TRANSDUCTION OF TYPE I INTERFERONS IN MALIGNANCYR01CA077816 · UNIVERSITY OF ILLINOIS AT CHICAGO · 1998 to 2005
$1.5M
Identifying the mechanisms of leukemia progressionR35CA253096 · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2025 to 2025
$1.1M
Bioinformatics Analysis of Next Generation Sequencing Data from Cancer CellsR50CA221848 · NORTHWESTERN UNIVERSITY · 2025 to 2025
$230k
CSRD VA I01 CX000916NCI NIH HHS P01 CA108671NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA077816NCI NIH HHS R01 CA121192NCI NIH HHS R35 CA253096NCI NIH HHS R50 CA221848NCI NIH HHS T32 CA009560
6 · The paper itself

Abstract

Defining the mechanisms that promote development and progression of myeloproliferative neoplasms (MPNs) is important for understanding the mechanisms of malignant hematopoiesis and critical development of new treatment approaches. We provide evidence for a key and essential role of the kinase ULK1 in MPN pathophysiology. Our studies demonstrate that genetic or pharmacological targeting of ULK1 delays substantially disease development in

Indexed as

Autophagy-Related Protein-1 HomologIntracellular Signaling Peptides and ProteinsMyeloproliferative DisordersAnimalsCell DifferentiationDisease Models, AnimalHematopoietic Stem CellsHumansJanus Kinase 2MiceMice, Inbred C57BLMutationSignal TransductionSpleenAutophagy-Related Protein-1 HomologIntracellular Signaling Peptides and ProteinsJak2 protein, mouseJanus Kinase 2Ulk1 protein, mousemyeloproliferative neoplasmssignalingtranscription regulationULK1

Identifiers

PMID40697155
PMCPMC12645588

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.