Evidence map›Paper›PMID 40697359›Full record

SynthesisFrontiers in aging neuroscience2025

Sedentary behavior, cognition, and brain health in older adults: a systematic review.

Marissa A Gogniat, Junyeon Won, Carlos Cruz, Amaya Aranda, Aryan Verma, Swathi Gujral, Andrea M Weinstein, Afsara B Zaheed, Keith R Cole, Kelsie M Full and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marissa A GogniatDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Junyeon WonInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States.
Carlos CruzInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States.
Amaya ArandaDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Aryan VermaInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States.
Swathi GujralDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Andrea M WeinsteinDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Afsara B ZaheedDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Keith R ColeVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, United States.
Kelsie M FullVanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, United States.
Beth E SnitzDepartment of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Funding

Intraindividual Cognitive Variability as an Early Marker of Alzheimer's DiseaseK23AG076663 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Andrea Weinstein · 2022 to 2026
$915k
NIA NIH HHS K23 AG076663
6 · The paper itself

Abstract

Sedentary behavior has been associated with poor health outcomes, especially in older adulthood. Given that sedentary behavior is a highly prevalent, modifiable health behavior, there has been a recent increased interest in examining how sedentary behavior relates to cognition and brain health. The current body of literature is limited and mixed. The purpose of this systematic review was to examine the associations of sedentary behavior with cognition and brain health in older adults across the cognitive spectrum. This study was pre-registered with PROSPERO (CRD42023477868). Six comprehensive databases were searched with pre-registered search terms. A total of 33 studies were included. Overall, results indicated that greater sedentary behavior was associated with worse cognition and brain health, although associations varied based on differences in measurement and classification of sedentary behavior. We discuss next steps and implications for future research.

Indexed as

Alzheimer’s diseasebrain healthcognitionolder adultsedentary behavior

Identifiers

PMID40697359
PMCPMC12279810

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.