ReviewiScience2025
Safety and toxicity risks of radiotherapy combined with PD-1/PD-L1 inhibitors: A comprehensive review.
Review in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- From local control to immune modulation: hypofractionated radiotherapy as a backbone for cancer immunotherapy.Frontiers in oncology · 2026Review
- Efficacy and Safety of Sintilimab in Combination With Anlotinib and Chemoradiotherapy as First-Line Treatment for Driver Gene-Negative Oligometastatic Non-small Cell Lung Cancer: A Real-World Cohort Study.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy (RT) combined with PD-1/PD-L1 Inhibitors has demonstrated remarkable efficacy across various cancers. However, concerns remain regarding its safety and potential toxicity. We analyze toxicity risks of RT combined with anti-PD-1/PD-L1 therapy based on current clinical studies. While a slight increase in grade 1-2 pneumonitis has been reported in patients with lung cancer, no consistent evidence suggests a rise in ≥ grade 3 pulmonary toxicity. Additionally, the combination appears well tolerated in the central nervous system, head and neck, and hepatic malignancies. This narrative review investigates key factors that may influence the risk of toxicity in combination therapy, including the dose and fractionation of RT, sequencing with immunotherapy, timing and duration of immune consolidation, and regimen heterogeneity. This review adheres to the SANRA (Scale for the Assessment of Narrative Review Articles) guidelines.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.