Evidence map›Paper›PMID 40697418›Full record

ArticleJournal of inflammation research2025

Anthrahydroquinone-2,6-Disulfonate Restores Lung Function in COPD Through Keap1/Nrf2 Pathway Activation.

Zhao Li, Jun Chen, Jiadong Zhang, Nan Li, Yang Yi, Hanjing Lu, Min Li, Rui Liu, Yuanpeng Chen, Xiaoran Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhao Li *College of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.ORCID 0009-0007-8970-5013
Jun Chen *Danzhou People's Hospital, Danzhou, Hainan, People's Republic of China.
Jiadong Zhang *College of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.
Nan LiCollege of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.
Yang YiCollege of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.ORCID 0000-0003-1493-0404
Hanjing LuCollege of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.
Min LiCollege of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.
Rui LiuCollege of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.
Yuanpeng ChenCollege of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.
Xiaoran LiuCollege of Emergency Trauma, Hainan Medical University, Haikou, Hainan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Chronic obstructive pulmonary disease (COPD), the third leading cause of death globally, is strongly driven by oxidative damage, contributing to lung function decline and high mortality. Despite advances in understanding oxidative stress in COPD pathogenesis, effective strategies to mitigate oxidative damage and normalize lung function remain a challenge. Anthrahydroquinone-2,6-disulfonate (AH Methods: This study induced COPD-like pathology by using LPS in combination with CS / CSE, establishing both in vivo and in vitro models to evaluate the effects of AH Results: AH Conclusion: AH

Indexed as

AH2QDSCOPDKeap1-Nrf2lung functionoxidative stress

Identifiers

PMID40697418
PMCPMC12282540

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.