Evidence map›Paper›PMID 40697488›Full record

ArticleBiological psychiatry global open science2025

Multilayered Epigenetic Analysis Identifies a Molecular Portrait for Psychological Resilience in Patients With Breast Cancer.

Corinna Richter, Olga Dethlefsen, Ulrika Axelsson, Kristina Lundberg, Lisa Rydén, Per Johnsson, Ulrika Ringdahl, Ingalill Rahm Hallberg, Carl A K Borrebaeck

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In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Corinna RichterCREATE Health Translational Cancer Center, Department of Immunotechnology, Lund University, Lund, Sweden.
Olga DethlefsenNational Bioinformatics Infrastructure, Science for Life Laboratory, Stockholm University, Stockholm, Sweden.
Ulrika AxelssonCREATE Health Translational Cancer Center, Department of Immunotechnology, Lund University, Lund, Sweden.
Kristina LundbergCREATE Health Translational Cancer Center, Department of Immunotechnology, Lund University, Lund, Sweden.
Lisa RydénDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Per JohnssonDepartment of Psychology, Lund University, Lund, Sweden.
Ulrika RingdahlCREATE Health Translational Cancer Center, Department of Immunotechnology, Lund University, Lund, Sweden.
Ingalill Rahm HallbergDepartment of Health Sciences, Lund University, Lund, Sweden.
Carl A K BorrebaeckCREATE Health Translational Cancer Center, Department of Immunotechnology, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Psychological resilience refers to a person's positive adaptation when faced with adversities, such as a breast cancer (BC) diagnosis. Highly resilient patients are more likely to regain stability and be protected from health conditions such as depression, anxiety, and posttraumatic stress disorder. We aimed to identify epigenetic markers that distinguish high- and low-resilient patients in a BC cohort at time of diagnosis. Methods: Genome-wide DNA methylation was determined in participants selected from a prospectively collected cohort of 1040 newly diagnosed BC patients with known resilience status. DNA methylation of those displaying the highest and lowest scores ( Results: DMPs and DMRs that consistently distinguished samples derived from high- and low-resilient patients were identified, and methylation differences followed a dose-response pattern related to resilience levels. DMRs included Conclusions:

Indexed as

BioinformaticsBiomarkerBreast cancerDNA methylationEpigeneticsPsychological resilience

Identifiers

PMID40697488
PMCPMC12281357

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.