Evidence map›Paper›PMID 40697548›Full record

SynthesisFrontiers in nutrition2025

Bioactive compounds in fermented foods: a systematic narrative review.

İbrahim Ender Künili, Vildan Akdeniz, Aslı Akpınar, Şebnem Öztürkoğlu Budak, José Antonio Curiel, Mustafa Guzel, Cem Karagözlü, Muzeyyen Berkel Kasikci, Grech Perry Mario Caruana, Małgorzata Starowicz and 6 more

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  2. The effects ofFrontiers in nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

İbrahim Ender KüniliDepartment of Fishing and Fish Processing Technology, Faculty of Marine Sciences and Technology, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye.
Vildan AkdenizDepartment of Dairy Technology, Faculty of Agriculture, Ege University, Izmir, Türkiye.
Aslı AkpınarDepartment of Food Engineering, Faculty of Engineering and Natural Science, Manisa Celal Bayar University, Manisa, Türkiye.
Şebnem Öztürkoğlu BudakDepartment of Dairy Technology, Faculty of Agriculture, Ankara University, Ankara, Türkiye.
José Antonio CurielDepartment of Food Technology, National Institute of Agricultural and Food Research and Technology (INIA-CSIC), Madrid, Spain.
Mustafa GuzelDepartment of Food Engineering, Hitit University, Corum, Türkiye.
Cem KaragözlüDepartment of Dairy Technology, Faculty of Agriculture, Ege University, Izmir, Türkiye.
Muzeyyen Berkel KasikciDepartment of Food Engineering, Faculty of Engineering and Natural Science, Manisa Celal Bayar University, Manisa, Türkiye.
Grech Perry Mario CaruanaDepartment of Food Sciences and Nutrition, Faculty of Health Sciences, University of Malta, Msida, Malta.
Małgorzata StarowiczDepartment of Chemistry and Biodynamics of Food, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland.
Christèle HumblotFrench National Research Institute for Sustainable Development (IRD), Montpellier, France.
Erhan KeyvanDepartment of Food Hygiene and Technology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Türkiye.
Christophe ChassardUnité Mixte de recherche sur le Fromage, INRAE, UCA, VetAgro Sup, Aurillac, France.
Smilja PracerInstitute for Biological Research Sinisa Stankovic, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Guy VergèresResearch Division Microbial Food Systems, Agroscope, Berne, Switzerland.
Harun KesenkaşDepartment of Dairy Technology, Faculty of Agriculture, Ege University, Izmir, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic narrative review aims to catalogue bioactive compounds that are formed during the fermentation process and identified as contributors to positive health outcomes in human clinical studies where fermented foods were used as dietary interventions. Under "The European Cooperation in Science and Technology" (COST) Action CA20128 - "Promoting Innovation of Fermented Foods" PIMENTO framework, a systematic literature search was conducted across PubMed, Scopus, and the Cochrane Library. The search initially identified 2,411 studies, of which 50 met the predefined inclusion criteria. In all included studies, fermented foods were used as nutritional interventions, and the bioactive compounds they contained were either hypothesised or directly analysed in relation to statistically significant health effects observed in humans. Findings were summarised in "Population, Intervention, Comparator, Outcome" (PICO)-structured tables and classified by health domain. The reported effects were grouped under the following categories: cardiovascular health, lipid metabolism, glucose regulation, immune modulation, neuroprotection, liver function, and other health outcomes. Across the included studies, a total of 31 bioactive compounds and/or compound groups were identified in fermented foods, including bioactive peptides, polyphenols (epicatechin, genistein), Systematic review registration: https://osf.io/jn8pf/.

Indexed as

bioactive compoundsclinical effectsclinical trialsfermentationfermented foodshealth benefits

Identifiers

PMID40697548
PMCPMC12282486

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.