ArticleWorld journal of diabetes2025
Breaking the diabetes-depression cycle: Exploring shared mechanisms, neuroinflammation, and emerging interventions for metabolic-mood comorbidities.
Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Multimorbidity Clusters and Depressive Symptom Networks in Old Age: Evidence From China.Psychiatry investigation · 2026Article
- Association of the cardiometabolic index and depressive symptoms with cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study.Scientific reports · 2026Article
- Protocol for a Systematic Review of Psychosocial Factors That Predict Mental Health Among Males Living with Type 2 Diabetes.International journal of environmental research and public health · 2026Article
- Joint association of depression and physical activity with incident cardiometabolic multimorbidity (CMM) among middle-aged and older adults in China.Scientific reports · 2026Article
- The relationship between fasting blood glucose, glycated hemoglobin, fructosamine, and depression in patients with type 2 diabetes mellitus in South Korea: a secondary analysis of the Korea National Health and Nutrition Examination Survey VIII-2 (2020) data.Journal of Korean biological nursing science · 2026Article
- Mechanisms of interaction between type 2 diabetes and psychological disorders and therapeutic interventions: a narrative review.Frontiers in medicine · 2026Review
- Depression and Its Association With Microvascular and Macrovascular Complications in Type 2 Diabetes.Journal of diabetes research · 2026Article
- The Potential Role of SGLT2 Inhibitors in the Treatment of Depression: Mechanisms and Clinical Prospects.Drug design, development and therapy · 2026Review
- Multi-omics exploration demonstrated the antidepressant effects of chrysophanol on diabetes-depression comorbidity rats via inflammatory, and neurodegenerative axes.Scientific reports · 2025Article
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Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article explores the bidirectional relationship between type 2 diabetes mellitus (T2DM) and depression, focusing on their shared pathophysiological mechanisms, including immune-inflammatory responses, gut-brain axis dysregulation, metabolic abnormalities, and neuroendocrine modulation. Research indicates that T2DM contributes to anxiety and depression through chronic low-grade inflammation, insulin resistance, gut microbiota imbalance, and hyperactivation of the hypothalamic-pituitary-adrenal axis. Conversely, depression may increase the risk of T2DM
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.