ArticleWorld journal of diabetes2025
Impact of intensive insulin therapy on dynamic cardiac function in critically ill patients with stress-induced hyperglycemia.
Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundStress-induced hyperglycemia (SIH) is common in critically ill patients and has been associated with adverse cardiovascular outcomes. Intensive insulin therapy (IIT) has been proposed to mitigate these risks by achieving tighter glycemic control.
aimTo evaluate the efficacy of IIT for managing SIH in critically ill patients and to explore its potential effect on cardiac function.
methodsA retrospective study was conducted at our hospital from January 2021 to December 2024, adhering to STROBE guidelines. A total of 186 critically ill patients were divided into normal glycemia (
resultsSIH markedly worsened haemodynamics versus normal glycaemia: RAP 9.8 ± 5.1
conclusionIIT significantly reduced cardiac filling pressures, improved cardiac function, and was associated with favorable clinical outcomes in SIH patients, suggesting potential benefits of stricter glycaemic control in critically ill patients. However, given the retrospective design and absence of glucose-variability monitoring, these findings should be interpreted with caution.
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