ArticleWorld journal of diabetes2025
Predictive ability of lipid indices for large-for-gestational-age infants in pregnant females with gestational diabetes mellitus.
Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Editorial: Neglected nuances in gestational diabetes.Frontiers in clinical diabetes and healthcare · 2025Article
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Authors and funding
8 authors.
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Abstract
backgroundThe primary complication associated with gestational diabetes mellitus (GDM) is delivery of an infant that is large for gestational age (LGA). Epidemiological findings have demonstrated that irregular lipid metabolism significantly contributes to insulin resistance, a key pathophysiological mechanism in GDM. However, the correlation between various lipid indices and the probability of delivering LGA infants remains inconsistent.
aimTo explore the relationships between lipid indices and the possibility of having LGA infants among GDM-affected pregnant females.
methodsBinary logistic regression methods were employed to evaluate the odds ratios and corresponding 95% confidence intervals for LGA according to five lipid indices. Restricted cubic spline models were applied to investigate dose-response relationships. The association between lipid indices and the risk of delivering LGA infants was further investigated among different subgroups. Receiver operating characteristic curves were utilized to assess the diagnostic performance of lipid indices.
resultsAcross crude and adjusted models, females with lipid indices in the upper two tertiles presented a markedly elevated risk of delivering LGA infants compared with the lowest tertile category. Conversely, high-density lipoprotein cholesterol levels demonstrated the contrary trend. Restricted cubic spline analyses revealed linear associations between the five lipid indices, except triglyceride levels, and the prevalence of LGA. The subgroup analysis highlighted that the correlation between lipid indices and the probability of LGA was inconsistent. The five lipid indices presented significant diagnostic efficacy, as indicated by receiver operating characteristic curve areas.
conclusionOur research demonstrated that lipid indices were effective predictors of the incidence of LGA infants in GDM-affected pregnancies irrespective of potential confounding factors.
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