Evidence map›Paper›PMID 40698124›Full record

ReviewActa pharmaceutica Sinica. B2025

Extracellular vesicles as biomarkers and drug delivery systems for tumor.

Xue Wang, Wenjing Chen, Wei Zeng, Kuanhan Feng, Yu Zheng, Ping Wang, Fucai Chen, Wen Zhang, Liuqing Di, Ruoning Wang

Abstract readReview
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xue WangSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Wenjing ChenSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Wei ZengSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Kuanhan FengSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Yu ZhengSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Ping WangSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Fucai ChenSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Wen ZhangSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Liuqing DiSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Ruoning WangSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are crucial for facilitating intercellular communication, promoting cell migration, and orchestrating the immune response. Recently, EVs can diagnose and treat tumors. EVs can be measured as biomarkers to provide information about the type of disease and therapeutic efficacy. Furthermore, EVs with lower immunogenicity and better biocompatibility are natural carriers of chemicals and gene drugs. Herein, we review the molecular composition, biogenesis, and separation methods of EVs. We also highlight the important role of EVs from different origins as biomarkers and drug delivery systems in tumor therapy. Finally, we provide deep insights into how EVs play a role in reversing the immunosuppressive microenvironment.

Indexed as

BiomarkersDrug delivery systemsDrug loading methodsExtracellular vesiclesMolecular compositionSeparation technologiesTumor immunotherapyTumor microenvironment

Identifiers

PMID40698124
PMCPMC12278421

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.