Evidence map›Paper›PMID 40698141›Full record

ReviewActa pharmaceutica Sinica. B2025

Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis.

Yufei Hui, Xue Jiao, Li Yang, Dejin Lu, Yanbo Han, Wen Yang, Yanli Cao, Yuxi Miao, Shiqiang Gong, Minjie Wei

Abstract readReview
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Beyond labeling: differential AcRegenerative biomaterials · 2026
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yufei HuiDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Xue JiaoDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Li YangDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Dejin LuDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Yanbo HanDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Wen YangDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Yanli CaoThe First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Yuxi MiaoDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Shiqiang GongDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Minjie WeiDepartment of Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have been widely used in the treatment of various autoimmune and inflammation-related diseases due to their potent immunomodulatory properties. Several studies have demonstrated that MSC-mediated immunomodulation is complex and bidirectional, with the

Indexed as

Autoimmune diseasesClinical therapeuticsImmune cellsImmunomodulatoryIndoleamine-2,3-dioxygenase (IDO)InflammationMesenchymal stem cells (MSCs)PlasticityTryptophan (Trp)

Identifiers

PMID40698141
PMCPMC12278408

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.