ArticleFrontiers in molecular neuroscience2025
Peripheral gene dysregulation in Negr1-deficient mice: insights into possible links with affective behavior.
Article in Frontiers in molecular neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Negr1 Deficiency Modulates Sex-Specific Neurobehavioral Adaptations to Social Isolation.Brain sciences · 2025Article
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5 authors.
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Abstract
Introduction: Neuronal growth regulator 1 (NEGR1) is a brain-enriched membrane protein with mild expression in peripheral tissues such as adipose tissue and skeletal muscle. Genome-wide association studies have implicated NEGR1 as a risk factor for human diseases including obesity, autism, and depression, but its molecular function remains poorly understood. Methods: To explore NEGR1's role in peripheral-to-brain communication, we conducted RNA-seq analysis on four peripheral tissues-intestine, skeletal muscle, liver, and epididymal white adipose tissue-collected from Results: The DEG analysis revealed dysregulation of ion channels and transporters, potentially contributing to AP-1-mediated inflammatory responses in peripheral tissues. Additionally, interleukin (IL)-17 signaling emerged as a key pathway that may mediate systemic inflammation in Discussion: These findings suggest a novel role for NEGR1 in modulating peripheral inflammatory responses and support the hypothesis that peripheral immune dysregulation may contribute to depressive-like behaviors in
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