ArticleEndocrine connections2025
Sex-specific differences in the association of magnesium intake with femoral neck bone mineral density among older adults.
Article in Endocrine connections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Early Supplementation with Branched-Chain Amino Acids Ameliorates Lipid Retention in Aortic Valves of ApoE-Knockout Mice.International journal of molecular sciences · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Magnesium plays a crucial role in bone metabolism, but its relationship with bone mineral density (BMD) remains complex and potentially sex-specific. This study aimed to investigate the association between magnesium intake and femoral neck BMD in older adults. Methods: We analyzed data from 1,343 adults aged ≥65 years in the 2017-2020 National Health and Nutrition Examination Survey, conducted by the National Center for Health Statistics in the United States. Magnesium intake was assessed using 24 h dietary recalls, and femoral neck BMD was measured by dual-energy X-ray absorptiometry. We employed weighted multivariate linear regression, subgroup analyses, and non-linear modeling techniques. Results: The fully adjusted model (controlling for demographic, clinical, lifestyle, nutritional, and biochemical factors) revealed a significant positive association between magnesium intake and femoral neck BMD (β = 0.0020 g/cm2 per 50 mg/d increase in magnesium intake, 95% CI: 0.0001, 0.0039, P = 0.042). This association was stronger in women and participants with BMI >30 kg/m2. In men, we identified a non-linear relationship with an inflection point at 480 mg/d magnesium intake, above which the positive association diminished. Conclusions: Our findings reveal complex, sex-specific relationships between magnesium intake and femoral neck BMD in older adults, highlighting the need for tailored dietary recommendations. The observed non-linear associations and threshold effects underscore the importance of optimal magnesium intake levels for bone health.
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