Evidence map›Paper›PMID 40698681›Full record

ReviewCurrent topics in medicinal chemistry2026

Carboxamide: A Privileged Pharmacophore for the Development of Anti-infectious and Anti-cancer Drugs.

Xiaopei Yang, Zirui Jiao, Kasemsiri Chandarajoti, Sai Lv, Xisong Ke, Wen Zhou

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaopei YangShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Zirui JiaoShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Kasemsiri ChandarajotiDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Sai LvShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.
Xisong KeCenter for Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No.1200, Cailun Road, Shanghai 201203, China.ORCID 0000-0001-7328-7354
Wen ZhouShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China.ORCID 0000-0002-3961-1816

Funding

National Natural Science Foundation of China 32473084, U22A20518
6 · The paper itself

Abstract

Carboxamide is a privileged scaffold that is often used in FDA-approved drugs. Unlike traditional amides, which exhibit properties similar to valence bonds, carboxamide has a more excellent binding mode and thus constructs rich pharmacological activities. According to the different working principles and N-terminus substitution of its specific structures, carboxamide can be further divided into N-unsubstituted carboxamide and N-substituted carboxamide. Both kinds of carboxamides have been widely studied and used in drug design and development. This review starts from the binding style and thus summarizes the excellent carboxamide structures, current research progress, and future challenges in the fields of anti-infection and anti-cancer.

Indexed as

AmidesAnti-Infective AgentsAntineoplastic AgentsHumansMolecular StructurePharmacophoreStructure-Activity RelationshipAmidesAnti-Infective AgentsAntineoplastic AgentsAnti-cancerAnti-infectionBinding modeCarboxamideN-terminus substitution

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.